PDF(Pubmed)
Abstract：
BACKGROUND: Adolescent substance use poses a critical public health challenge, intertwined with risk-taking behavior, criminality, functional impairment, and comorbid mental and physical health issues. Adolescents with bipolar spectrum disorders (BSD) exhibit heightened susceptibility to substance use, necessitating a nuanced exploration of the bipolar-substance use relationship.
METHODS: This study addressed gaps in the literature by employing a prospective, longitudinal design with 443 Philadelphia-area adolescents, tracking BSD symptoms and substance use. We predicted that BSD symptoms would be associated with increases in substance use, and that these effects would be more pronounced for individuals with a BSD and those with high reward sensitivity.
RESULTS: Hypomanic symptoms predicted subsequent substance use, with a stronger association observed in individuals diagnosed with BSD. Contrary to expectations, depressive symptoms did not exhibit a similar relationship. Although the hypothesized moderating role of reward sensitivity was not supported, higher reward sensitivity predicted increased substance use.
CONCLUSIONS: Symptoms and substance use are only captured for the month prior to each session due to the assessment timeline. This highlights the benefits of frequent assessments over a shorter time frame to monitor real-time changes. Alternative classification methods for reward sensitivity, such as brain or behavior-based assessments, might yield different results.
CONCLUSIONS: This study\'s contributions include evaluating substance use broadly, utilizing a longitudinal design for temporal clarity, and shifting the focus from substance use predicting mood symptoms to the inverse. The findings underscore the need for continued exploration of mood symptom predictors of substance use, emphasizing the role of reward sensitivity.
METHODS: This study addressed gaps in the literature by employing a prospective, longitudinal design with 443 Philadelphia-area adolescents, tracking BSD symptoms and substance use. We predicted that BSD symptoms would be associated with increases in substance use, and that these effects would be more pronounced for individuals with a BSD and those with high reward sensitivity.
RESULTS: Hypomanic symptoms predicted subsequent substance use, with a stronger association observed in individuals diagnosed with BSD. Contrary to expectations, depressive symptoms did not exhibit a similar relationship. Although the hypothesized moderating role of reward sensitivity was not supported, higher reward sensitivity predicted increased substance use.
CONCLUSIONS: Symptoms and substance use are only captured for the month prior to each session due to the assessment timeline. This highlights the benefits of frequent assessments over a shorter time frame to monitor real-time changes. Alternative classification methods for reward sensitivity, such as brain or behavior-based assessments, might yield different results.
CONCLUSIONS: This study\'s contributions include evaluating substance use broadly, utilizing a longitudinal design for temporal clarity, and shifting the focus from substance use predicting mood symptoms to the inverse. The findings underscore the need for continued exploration of mood symptom predictors of substance use, emphasizing the role of reward sensitivity.
摘要：
背景：青少年物质使用构成了严重的公共卫生挑战，与冒险行为交织在一起，犯罪,功能损害，精神和身体健康问题并存。患有双相谱系障碍（BSD）的青少年表现出对物质使用的敏感性更高，需要对两极物质使用关系进行细微差别的探索。
方法：本研究通过采用前瞻性，纵向设计有443名费城地区青少年，跟踪BSD症状和物质使用。我们预测BSD症状将与物质使用的增加有关，对于具有BSD的个体和具有高奖励敏感性的个体，这些影响将更加明显。
结果：轻躁狂症状预测随后的药物使用，在诊断为BSD的个体中观察到更强的关联。与预期相反,抑郁症状没有表现出类似的关系.尽管假设的奖励敏感性的调节作用没有得到支持，较高的奖励敏感性预示着物质使用的增加。
结论：由于评估时间表，症状和药物使用情况仅在每次治疗前一个月被捕获。这突出了在较短的时间范围内进行频繁评估以监控实时变化的好处。奖励敏感性的替代分类方法，例如基于大脑或行为的评估，可能会产生不同的结果。
结论：这项研究的贡献包括广泛评估药物使用，利用纵向设计的时间清晰度，并将重点从物质使用预测情绪症状转移到相反。研究结果强调需要继续探索物质使用的情绪症状预测因子，强调奖励敏感性的作用。
方法：本研究通过采用前瞻性，纵向设计有443名费城地区青少年，跟踪BSD症状和物质使用。我们预测BSD症状将与物质使用的增加有关，对于具有BSD的个体和具有高奖励敏感性的个体，这些影响将更加明显。
结果：轻躁狂症状预测随后的药物使用，在诊断为BSD的个体中观察到更强的关联。与预期相反,抑郁症状没有表现出类似的关系.尽管假设的奖励敏感性的调节作用没有得到支持，较高的奖励敏感性预示着物质使用的增加。
结论：由于评估时间表，症状和药物使用情况仅在每次治疗前一个月被捕获。这突出了在较短的时间范围内进行频繁评估以监控实时变化的好处。奖励敏感性的替代分类方法，例如基于大脑或行为的评估，可能会产生不同的结果。
结论：这项研究的贡献包括广泛评估药物使用，利用纵向设计的时间清晰度，并将重点从物质使用预测情绪症状转移到相反。研究结果强调需要继续探索物质使用的情绪症状预测因子，强调奖励敏感性的作用。
