关键词: Brain PSTBP Pituitary Pufferfish TTX

Mesh : Animals Tetrodotoxin / metabolism Pituitary Gland / metabolism Saxitoxin Takifugu / metabolism Brain / metabolism Fish Proteins / metabolism Sodium Channels

来  源:   DOI:10.1016/j.toxicon.2024.107777

Abstract:
Pufferfish saxitoxin- and tetrodotoxin (TTX)-binding protein (PSTBP) is considered to transfer TTX between tissues. The immunohistochemical distribution of PSTBP-homolog (PSTBPh) and TTX in the brain and pituitary of hatchery-reared juvenile tiger puffer Takifugu rubripes was investigated. PSTBPh was observed mainly in the pars intermedia of the pituitary. TTX was only detected in a TTX-fed fish in the neurohypophysis of the pituitary and in several other brain regions. The relationship between PSTBPh and TTX is discussed.
摘要:
认为河豚毒素和河豚毒素(TTX)结合蛋白(PSTBP)在组织之间转移TTX。研究了PSTBP同源物(PSTBPh)和TTX在孵化场饲养的幼虎河豚Takifugurubbypes的脑和垂体中的免疫组织化学分布。PSTBPh主要在垂体的中间段中观察到。TTX仅在垂体神经垂体和其他几个大脑区域的TTX喂养鱼中检测到。讨论了PSTBPh与TTX之间的关系。
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