Abstract：
Substance use disorder (SUD) exacerbates the impact of Long-COVID, particularly increasing the risk of taste and olfactory disorders. Analyzing retrospective cohort data from TriNetX and over 33 million records (Jan 2020-Dec 2022), this study focused on 1,512,358 participants, revealing that SUD significantly heightens the likelihood of experiencing taste disturbances and anosmia in Long-COVID sufferers. Results indicated that individuals with SUD face a higher incidence of sensory impairments compared to controls, with older adults and women being particularly vulnerable. Smokers with SUD were found to have an increased risk of olfactory and taste dysfunctions. The findings underscore the importance of early screening, diagnosis, and interventions for Long-COVID patients with a history of SUD, suggesting a need for clinicians to monitor for depression and anxiety linked to sensory dysfunction for comprehensive care.
摘要：
物质使用障碍(SUD)加剧了长发COVID的影响，特别是增加味觉和嗅觉障碍的风险。分析来自TriNetX的回顾性队列数据和超过3300万条记录（2020年1月至2022年12月），这项研究集中于1,512,358名参与者，揭示SUD显着增加了长期COVID患者经历味觉障碍和嗅觉缺失的可能性。结果表明，与对照组相比，SUD患者的感觉障碍发生率更高，老年人和妇女尤其脆弱。发现患有SUD的吸烟者患嗅觉和味觉障碍的风险增加。这些发现强调了早期筛查的重要性，诊断,以及对有SUD病史的长型COVID患者的干预措施，提示临床医生需要监测与感觉功能障碍相关的抑郁和焦虑，以进行全面护理。
