METHODS: This study conducted a 6-year comprehensive review of 65 eye cytology cases received at a tertiary level hospital. Cytopathologic diagnoses of \"negative for malignancy\" and \"atypical\" were categorized as negative findings (70.8%, n = 46) and diagnoses of \"suspicious for malignancy\" and \"positive for malignancy\" were categorized as positive findings (23.1%, n = 15). A 44.6% (n = 29) of cases had subsequent histopathology and/or flow cytometry diagnoses. Premalignant and malignant lesions detected on histopathology were considered as significant findings. Statistical analysis was performed to evaluate the concordance of ocular cytology with associated histopathology and/or flow cytometry diagnoses.
RESULTS: The accuracy of final cytology-histopathology and/or cytology-flow cytometry diagnoses in this cohort of cases is 86.2%. The sensitivity and specificity of ocular diagnosis by cytology are 66.6% and 100%, respectively. The positive and negative predictive values of ocular diagnosis by cytology are 100% and 80.9%, respectively.
CONCLUSIONS: Ocular cytology is a fast, effective, and sensitive method for diagnosing ocular pathology specimens. Familiarity with these specimen types by cytopathologists can help in diagnosing ocular diseases effectively on small, challenging cytologic preparations.
方法:本研究对三级医院接收的65例眼部细胞学病例进行了为期6年的综合审查。细胞病理学诊断为“恶性肿瘤阴性”和“非典型”被归类为阴性发现(70.8%,n=46),诊断为“可疑恶性肿瘤”和“恶性肿瘤阳性”被归类为阳性发现(23.1%,n=15)。44.6%(n=29)的病例随后进行了组织病理学和/或流式细胞术诊断。在组织病理学上检测到的癌前病变和恶性病变被认为是重要的发现。进行统计分析以评估眼细胞学与相关组织病理学和/或流式细胞术诊断的一致性。
结果:在这一组病例中,最终细胞学-组织病理学和/或细胞学-流式细胞术诊断的准确性为86.2%。眼部细胞学诊断的敏感性和特异性分别为66.6%和100%,分别。眼部细胞学诊断的阳性预测值和阴性预测值分别为100%和80.9%,分别。
结论:眼部细胞学检查是一种快速,有效,和诊断眼部病理标本的敏感方法。熟悉这些标本类型的细胞病理学家可以帮助诊断眼部疾病有效的小,具有挑战性的细胞学制剂。