Abstract：
BACKGROUND: Ocular cytology is an effective method of diagnosing infective, benign, and malignant ocular disease processes due to easy accessibility and rapid turnaround time. However, these specimens pose significant diagnostic challenges due to rarity of the specimen type, sparse diagnostic material available for ancillary workup, and unfamiliarity of the diagnostic entities by the cytopathologist.
METHODS: This study conducted a 6-year comprehensive review of 65 eye cytology cases received at a tertiary level hospital. Cytopathologic diagnoses of \"negative for malignancy\" and \"atypical\" were categorized as negative findings (70.8%, n = 46) and diagnoses of \"suspicious for malignancy\" and \"positive for malignancy\" were categorized as positive findings (23.1%, n = 15). A 44.6% (n = 29) of cases had subsequent histopathology and/or flow cytometry diagnoses. Premalignant and malignant lesions detected on histopathology were considered as significant findings. Statistical analysis was performed to evaluate the concordance of ocular cytology with associated histopathology and/or flow cytometry diagnoses.
RESULTS: The accuracy of final cytology-histopathology and/or cytology-flow cytometry diagnoses in this cohort of cases is 86.2%. The sensitivity and specificity of ocular diagnosis by cytology are 66.6% and 100%, respectively. The positive and negative predictive values of ocular diagnosis by cytology are 100% and 80.9%, respectively.
CONCLUSIONS: Ocular cytology is a fast, effective, and sensitive method for diagnosing ocular pathology specimens. Familiarity with these specimen types by cytopathologists can help in diagnosing ocular diseases effectively on small, challenging cytologic preparations.
METHODS: This study conducted a 6-year comprehensive review of 65 eye cytology cases received at a tertiary level hospital. Cytopathologic diagnoses of \"negative for malignancy\" and \"atypical\" were categorized as negative findings (70.8%, n = 46) and diagnoses of \"suspicious for malignancy\" and \"positive for malignancy\" were categorized as positive findings (23.1%, n = 15). A 44.6% (n = 29) of cases had subsequent histopathology and/or flow cytometry diagnoses. Premalignant and malignant lesions detected on histopathology were considered as significant findings. Statistical analysis was performed to evaluate the concordance of ocular cytology with associated histopathology and/or flow cytometry diagnoses.
RESULTS: The accuracy of final cytology-histopathology and/or cytology-flow cytometry diagnoses in this cohort of cases is 86.2%. The sensitivity and specificity of ocular diagnosis by cytology are 66.6% and 100%, respectively. The positive and negative predictive values of ocular diagnosis by cytology are 100% and 80.9%, respectively.
CONCLUSIONS: Ocular cytology is a fast, effective, and sensitive method for diagnosing ocular pathology specimens. Familiarity with these specimen types by cytopathologists can help in diagnosing ocular diseases effectively on small, challenging cytologic preparations.
摘要：
背景：眼部细胞学检查是诊断感染性疾病的有效方法，良性,和恶性眼病过程由于容易获得和快速的周转时间。然而,由于标本类型的稀有性，这些标本构成了重大的诊断挑战，可用于辅助检查的稀疏诊断材料，以及细胞病理学家对诊断实体的不熟悉。
方法：本研究对三级医院接收的65例眼部细胞学病例进行了为期6年的综合审查。细胞病理学诊断为“恶性肿瘤阴性”和“非典型”被归类为阴性发现（70.8％，n=46），诊断为“可疑恶性肿瘤”和“恶性肿瘤阳性”被归类为阳性发现（23.1％，n=15)。44.6％（n=29）的病例随后进行了组织病理学和/或流式细胞术诊断。在组织病理学上检测到的癌前病变和恶性病变被认为是重要的发现。进行统计分析以评估眼细胞学与相关组织病理学和/或流式细胞术诊断的一致性。
结果：在这一组病例中，最终细胞学-组织病理学和/或细胞学-流式细胞术诊断的准确性为86.2%。眼部细胞学诊断的敏感性和特异性分别为66.6%和100%,分别。眼部细胞学诊断的阳性预测值和阴性预测值分别为100%和80.9%,分别。
结论：眼部细胞学检查是一种快速，有效,和诊断眼部病理标本的敏感方法。熟悉这些标本类型的细胞病理学家可以帮助诊断眼部疾病有效的小，具有挑战性的细胞学制剂。
方法：本研究对三级医院接收的65例眼部细胞学病例进行了为期6年的综合审查。细胞病理学诊断为“恶性肿瘤阴性”和“非典型”被归类为阴性发现（70.8％，n=46），诊断为“可疑恶性肿瘤”和“恶性肿瘤阳性”被归类为阳性发现（23.1％，n=15)。44.6％（n=29）的病例随后进行了组织病理学和/或流式细胞术诊断。在组织病理学上检测到的癌前病变和恶性病变被认为是重要的发现。进行统计分析以评估眼细胞学与相关组织病理学和/或流式细胞术诊断的一致性。
结果：在这一组病例中，最终细胞学-组织病理学和/或细胞学-流式细胞术诊断的准确性为86.2%。眼部细胞学诊断的敏感性和特异性分别为66.6%和100%,分别。眼部细胞学诊断的阳性预测值和阴性预测值分别为100%和80.9%,分别。
结论：眼部细胞学检查是一种快速，有效,和诊断眼部病理标本的敏感方法。熟悉这些标本类型的细胞病理学家可以帮助诊断眼部疾病有效的小，具有挑战性的细胞学制剂。
