Abstract：
UNASSIGNED: Leptin plays a role in regulating energy balance, immunity, and inflammation. Studies suggest higher leptin levels might be associated with various autoimmune diseases. Most of them were in adult. To our knowledge, our study is one of the few that describe serum leptin level and leptin gene polymorphism in children with autoimmune hepatitis (AIH).
UNASSIGNED: Our study aims to explore the association between serum leptin level and genetic variations in leptin gene with the likelihood of AIH in children.
UNASSIGNED: Thirty-one children with AIH and 29 healthy children serving as a control group were included. Serum leptin levels were measured by ELISA assays. Leptin rs2167270 genotyping was done using the real time-PCR. The relationship of serum leptin level and leptin gene polymorphism with patients\' data was studied. Patients follow up to assess treatment response.
UNASSIGNED: Children with AIH had significantly higher levels of leptin compared to healthy controls. GG genotype was significantly more prevalent in the AIH group compared to controls.
UNASSIGNED: High serum leptin levels and leptin gene polymorphism may play a role in AIH development. It is worthy to recognize if leptin can serve as diagnostic and/or therapeutic target in AIH in children.
UNASSIGNED: Our study aims to explore the association between serum leptin level and genetic variations in leptin gene with the likelihood of AIH in children.
UNASSIGNED: Thirty-one children with AIH and 29 healthy children serving as a control group were included. Serum leptin levels were measured by ELISA assays. Leptin rs2167270 genotyping was done using the real time-PCR. The relationship of serum leptin level and leptin gene polymorphism with patients\' data was studied. Patients follow up to assess treatment response.
UNASSIGNED: Children with AIH had significantly higher levels of leptin compared to healthy controls. GG genotype was significantly more prevalent in the AIH group compared to controls.
UNASSIGNED: High serum leptin levels and leptin gene polymorphism may play a role in AIH development. It is worthy to recognize if leptin can serve as diagnostic and/or therapeutic target in AIH in children.
摘要：
■瘦素在调节能量平衡中起作用，豁免权,和炎症。研究表明，较高的瘦素水平可能与各种自身免疫性疾病有关。他们中的大多数都是成年人。据我们所知,我们的研究是少数描述自身免疫性肝炎（AIH）儿童血清瘦素水平和瘦素基因多态性的研究之一。
■我们的研究旨在探讨血清瘦素水平和瘦素基因遗传变异与儿童AIH可能性之间的关系。
■31名AIH儿童和29名健康儿童作为对照组。通过ELISA测定法测量血清瘦素水平。使用实时PCR进行瘦素rs2167270基因分型。研究了血清瘦素水平和瘦素基因多态性与患者数据的关系。患者随访以评估治疗反应。
■AIH患儿的瘦素水平明显高于健康对照组。与对照组相比，GG基因型在AIH组中明显更普遍。
■高血清瘦素水平和瘦素基因多态性可能在AIH的发展中起作用。瘦素是否可以作为儿童AIH的诊断和/或治疗靶标值得认识。
■我们的研究旨在探讨血清瘦素水平和瘦素基因遗传变异与儿童AIH可能性之间的关系。
■31名AIH儿童和29名健康儿童作为对照组。通过ELISA测定法测量血清瘦素水平。使用实时PCR进行瘦素rs2167270基因分型。研究了血清瘦素水平和瘦素基因多态性与患者数据的关系。患者随访以评估治疗反应。
■AIH患儿的瘦素水平明显高于健康对照组。与对照组相比，GG基因型在AIH组中明显更普遍。
■高血清瘦素水平和瘦素基因多态性可能在AIH的发展中起作用。瘦素是否可以作为儿童AIH的诊断和/或治疗靶标值得认识。
