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Abstract：
UNASSIGNED: To explore the correlation between the vessel density (VD) of the retina and choroid vascular plexuses and the thicknesses of their respective retinal layers and choroid membranes in participants with severe non-proliferative diabetic retinopathy (NPDR).
UNASSIGNED: We retrospectively analyzed the data of 42 eyes of 42 participants with diabetes mellitus (DM) and severe NPDR. In addition, 41 eyes of 41 healthy controls were evaluated. Measurements were taken for both groups using optical coherence tomography angiography (OCTA), including the area and perimeter of the foveal vascular zone (FAZ) and the vascular density (VD) in the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choroid capillary (CC). These measurements were compared with the retinal thickness (RT) of the inner/intermediate retinal layers and choroidal thickness (CT). The study evaluated the correlation between RT or CT and VD in the respective vascular networks, namely superficial capillary plexus (SCP), deep capillary plexus (DCP), or CC.
UNASSIGNED: The inner RT and VD in all plexuses were significantly lower in the severe NPDR group than in the healthy controls. Furthermore, the FAZ area and perimeter were larger in the severe NPDR group. Inner RT was correlated with VD in the SCP group (r=0.67 and r=0.71 in the healthy control and severe NPDR groups, respectively; p<0.05). CT negatively correlated with VD in the CC (r=-0.697 and r=-0.759 in the healthy control and severe NPDR groups, respectively; p<0.05). Intermediate RT significantly correlated with VD in the DCP of the severe NPDR group (r=-0.55, p<0.05), but not in the healthy control group.
UNASSIGNED: Retinal or choroidal thickness strongly correlated with VD. Therefore, patients with severe NPDR must consider the distinct anatomical and functional entities of the various retinal layers and the choroid.
UNASSIGNED: We retrospectively analyzed the data of 42 eyes of 42 participants with diabetes mellitus (DM) and severe NPDR. In addition, 41 eyes of 41 healthy controls were evaluated. Measurements were taken for both groups using optical coherence tomography angiography (OCTA), including the area and perimeter of the foveal vascular zone (FAZ) and the vascular density (VD) in the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choroid capillary (CC). These measurements were compared with the retinal thickness (RT) of the inner/intermediate retinal layers and choroidal thickness (CT). The study evaluated the correlation between RT or CT and VD in the respective vascular networks, namely superficial capillary plexus (SCP), deep capillary plexus (DCP), or CC.
UNASSIGNED: The inner RT and VD in all plexuses were significantly lower in the severe NPDR group than in the healthy controls. Furthermore, the FAZ area and perimeter were larger in the severe NPDR group. Inner RT was correlated with VD in the SCP group (r=0.67 and r=0.71 in the healthy control and severe NPDR groups, respectively; p<0.05). CT negatively correlated with VD in the CC (r=-0.697 and r=-0.759 in the healthy control and severe NPDR groups, respectively; p<0.05). Intermediate RT significantly correlated with VD in the DCP of the severe NPDR group (r=-0.55, p<0.05), but not in the healthy control group.
UNASSIGNED: Retinal or choroidal thickness strongly correlated with VD. Therefore, patients with severe NPDR must consider the distinct anatomical and functional entities of the various retinal layers and the choroid.
摘要：
■探讨重度非增生性糖尿病视网膜病变（NPDR）参与者视网膜和脉络膜血管丛的血管密度（VD）与其各自视网膜层和脉络膜厚度之间的相关性。
■我们回顾性分析了42例糖尿病（DM）和严重NPDR患者的42只眼的数据。此外,对41例健康对照者的41只眼进行了评价。使用光学相干断层扫描血管造影（OCTA）对两组进行测量，包括中央凹血管区（FAZ）的面积和周长以及浅表毛细血管丛（SCP）中的血管密度（VD），深毛细血管丛（DCP），和脉络膜毛细血管（CC）。将这些测量值与内部/中间视网膜层的视网膜厚度（RT）和脉络膜厚度（CT）进行比较。该研究评估了相应血管网络中RT或CT与VD之间的相关性，即浅表毛细血管丛（SCP），深毛细血管丛（DCP），或CC。
■重度NPDR组所有丛的内部RT和VD均显着低于健康对照组。此外，重度NPDR组的FAZ面积和周长较大.SCP组的内部RT与VD相关（健康对照组和严重NPDR组的r=0.67和r=0.71，分别为；p<0.05)。在CC中，CT与VD呈负相关（在健康对照组和严重NPDR组中，r=-0.697和r=-0.759，分别为；p<0.05)。重度NPDR组DCP的中间RT与VD显著相关(r=-0.55,p<0.05),但不是健康对照组。
■视网膜或脉络膜厚度与VD密切相关。因此,患有严重NPDR的患者必须考虑不同视网膜层和脉络膜的不同解剖和功能实体.
■我们回顾性分析了42例糖尿病（DM）和严重NPDR患者的42只眼的数据。此外,对41例健康对照者的41只眼进行了评价。使用光学相干断层扫描血管造影（OCTA）对两组进行测量，包括中央凹血管区（FAZ）的面积和周长以及浅表毛细血管丛（SCP）中的血管密度（VD），深毛细血管丛（DCP），和脉络膜毛细血管（CC）。将这些测量值与内部/中间视网膜层的视网膜厚度（RT）和脉络膜厚度（CT）进行比较。该研究评估了相应血管网络中RT或CT与VD之间的相关性，即浅表毛细血管丛（SCP），深毛细血管丛（DCP），或CC。
■重度NPDR组所有丛的内部RT和VD均显着低于健康对照组。此外，重度NPDR组的FAZ面积和周长较大.SCP组的内部RT与VD相关（健康对照组和严重NPDR组的r=0.67和r=0.71，分别为；p<0.05)。在CC中，CT与VD呈负相关（在健康对照组和严重NPDR组中，r=-0.697和r=-0.759，分别为；p<0.05)。重度NPDR组DCP的中间RT与VD显著相关(r=-0.55,p<0.05),但不是健康对照组。
■视网膜或脉络膜厚度与VD密切相关。因此,患有严重NPDR的患者必须考虑不同视网膜层和脉络膜的不同解剖和功能实体.
