PDF(Pubmed)
Abstract：
UNASSIGNED: Higher prevalence of obesity has been observed among women compared to men, which can be explained partly by the higher consumption of sweets and physical inactivity. Obesity can alter immune cell infiltration, and therefore increase the susceptibility to develop chronic inflammation and metabolic disorders. In this study, we aimed to explore the association between free sugar intake and other unhealthy lifestyle habits in relation to the proportion of circulating iNKT cells among women with healthy weight and women experiencing overweight and obesity.
UNASSIGNED: A cross-sectional study was conducted on 51 Saudi women > 18 years, wherein their daily free sugar intake was assessed using the validated Food Frequency Questionnaire. Data on smoking status, physical activity, and supplement use were also collected. Anthropometric data including height, weight, waist circumference were objectively measured from each participants. The proportion of circulating iNKT cells was determined using flow cytometry.
UNASSIGNED: Smoking, physical activity, supplement use, and weight status were not associated with proportion of circulating iNKT cells. Significant association was found between proportion of circulating iNKT cells and total free sugar intake and free sugar intake coming from solid food sources only among women experiencing overweight and obesity (Beta: -0.10: Standard Error: 0.04 [95% Confidence Interval: -0.18 to -0.01], p= 0.034) and (Beta: -0.15: Standard Error: 0.05 [95% Confidence Interval: -0.25 to -0.05], p= 0.005), respectively.
UNASSIGNED: Excessive free sugar consumption may alter iNKT cells and consequently increase the risk for chronic inflammation and metabolic disorders.
UNASSIGNED: A cross-sectional study was conducted on 51 Saudi women > 18 years, wherein their daily free sugar intake was assessed using the validated Food Frequency Questionnaire. Data on smoking status, physical activity, and supplement use were also collected. Anthropometric data including height, weight, waist circumference were objectively measured from each participants. The proportion of circulating iNKT cells was determined using flow cytometry.
UNASSIGNED: Smoking, physical activity, supplement use, and weight status were not associated with proportion of circulating iNKT cells. Significant association was found between proportion of circulating iNKT cells and total free sugar intake and free sugar intake coming from solid food sources only among women experiencing overweight and obesity (Beta: -0.10: Standard Error: 0.04 [95% Confidence Interval: -0.18 to -0.01], p= 0.034) and (Beta: -0.15: Standard Error: 0.05 [95% Confidence Interval: -0.25 to -0.05], p= 0.005), respectively.
UNASSIGNED: Excessive free sugar consumption may alter iNKT cells and consequently increase the risk for chronic inflammation and metabolic disorders.
摘要：
■与男性相比，女性的肥胖患病率更高，这可以部分解释为更高的糖果消费和缺乏体力活动。肥胖可以改变免疫细胞浸润,并因此增加发展为慢性炎症和代谢紊乱的易感性。在这项研究中,我们旨在探讨游离糖摄入和其他不健康生活习惯与健康体重女性和超重和肥胖女性循环iNKT细胞比例之间的关系.
■对51名18岁以上的沙特女性进行了横断面研究，其中使用经过验证的食物频率问卷评估他们的每日游离糖摄入量。关于吸烟状况的数据，身体活动,和补充使用也被收集。人体测量数据，包括身高，体重,对每位参与者的腰围进行了客观测量.使用流式细胞术确定循环iNKT细胞的比例。
■吸烟，身体活动,补充使用,和体重状态与循环iNKT细胞的比例无关。仅在超重和肥胖的女性中，循环iNKT细胞的比例与总游离糖摄入量和来自固体食物来源的游离糖摄入量之间存在显着关联（Beta：-0.10：标准误差：0.04[95％置信区间：-0.18至-0.01]，p=0.034）和（Beta：-0.15：标准误差：0.05[95％置信区间：-0.25至-0.05]，p=0.005),分别。
■过量的游离糖消耗可能会改变iNKT细胞，从而增加慢性炎症和代谢紊乱的风险。
■对51名18岁以上的沙特女性进行了横断面研究，其中使用经过验证的食物频率问卷评估他们的每日游离糖摄入量。关于吸烟状况的数据，身体活动,和补充使用也被收集。人体测量数据，包括身高，体重,对每位参与者的腰围进行了客观测量.使用流式细胞术确定循环iNKT细胞的比例。
■吸烟，身体活动,补充使用,和体重状态与循环iNKT细胞的比例无关。仅在超重和肥胖的女性中，循环iNKT细胞的比例与总游离糖摄入量和来自固体食物来源的游离糖摄入量之间存在显着关联（Beta：-0.10：标准误差：0.04[95％置信区间：-0.18至-0.01]，p=0.034）和（Beta：-0.15：标准误差：0.05[95％置信区间：-0.25至-0.05]，p=0.005),分别。
■过量的游离糖消耗可能会改变iNKT细胞，从而增加慢性炎症和代谢紊乱的风险。
