■营养化合物在DNA复制中起关键作用,维护,修复,并作为抗氧化剂和抗炎剂。充足的膳食摄入量支持基因组稳定性并保持健康。
■为了调查膳食模式之间的关联,包括摄入必需的营养素和添加的糖,在中年黑人和白人女性的不同队列中,已建立和新的营养指数的饮食质量得分与表观遗传年龄。
■这项横断面研究包括对1987-1997年国家心脏的过去女性参与者的分析(2021-2023年),肺,和血液研究所生长与健康研究(NGHS),该研究在9至19岁的黑人和白人女性社区队列中检查了心血管健康状况。在2015年至2019年期间从NGHS的加利福尼亚网站招募的这些参与者中,342名女性接受了有效的完整饮食和表观遗传评估。数据从2021年10月到2023年11月进行了分析。
■已建立的营养指数的饮食质量评分(替代地中海饮食[aMED],替代健康饮食指数[AHEI]-2010);一部小说的分数,先验开发的表观遗传营养指数[ENI];和平均添加糖摄入量来自3天的食物记录。
■GrimAge2,第二代表观遗传时钟标记,是从唾液DNA计算的。假设是在数据收集后提出的。据推测,更健康的饮食指标与年轻的表观遗传年龄有关。
■总共342名女性组成了分析样本(平均[SD]年龄,39.2[1.1]年;171[50.0%]黑人和171[50.0%]白人参与者)。在完全调整的模型中,aMED(β,-0.41;95%CI,-0.69至-0.13),AHEI-2010(β,-0.05;95%CI,-0.08至-0.01),和ENI(β,-0.17;95%CI,-0.29至-0.06)分数,和添加的糖摄入量(β,0.02;95%CI,0.01-0.04)在预期方向上与GrimAge2均显着相关。在综合分析中,上述GrimAge2的结果得以保留,aMED和添加糖摄入量的相关估计值保持其统计学显著性.
■在这项横断面研究中,观察到健康饮食和添加糖摄入与表观遗传年龄的独立关联.据我们所知,这些是首次使用第二代表观遗传时钟证明添加糖摄入量与表观遗传衰老之间存在关联的发现,也是首次将分析扩展到中年黑人和白人女性的不同人群的发现之一.促进符合慢性疾病预防建议的饮食,并富含抗氧化剂或抗炎和促表观遗传健康营养素,同时强调低添加糖的消耗可能会支持相对于实际年龄的细胞衰老速度较慢。虽然需要纵向分析。
UNASSIGNED: Nutritive compounds play critical roles in DNA replication, maintenance, and repair, and also serve as antioxidant and anti-inflammatory agents. Sufficient dietary intakes support genomic stability and preserve health.
UNASSIGNED: To investigate the associations of dietary patterns, including intakes of essential nutrients and added sugar, and diet quality scores of established and new nutrient indices with epigenetic age in a diverse cohort of Black and White women at midlife.
UNASSIGNED: This cross-sectional study included analyses (2021-2023) of past women participants of the 1987-1997 National Heart, Lung, and Blood Institute Growth and Health Study (NGHS), which examined cardiovascular health in a community cohort of Black and White females aged between 9 and 19 years. Of these participants who were recruited between 2015 and 2019 from NGHS\'s California site, 342 females had valid completed diet and epigenetic assessments. The data were analyzed from October 2021 to November 2023.
UNASSIGNED: Diet quality scores of established nutrient indices (Alternate Mediterranean Diet [aMED], Alternate Healthy Eating Index [AHEI]-2010); scores for a novel, a priori-developed Epigenetic Nutrient Index [ENI]; and mean added sugar intake amounts were derived from 3-day food records.
UNASSIGNED: GrimAge2, a second-generation epigenetic clock marker, was calculated from salivary DNA. Hypotheses were formulated after data collection. Healthier diet indicators were hypothesized to be associated with younger epigenetic age.
UNASSIGNED: A total of 342 women composed the analytic sample (mean [SD] age, 39.2 [1.1] years; 171 [50.0%] Black and 171 [50.0%] White participants). In fully adjusted models, aMED (β, -0.41; 95% CI, -0.69 to -0.13), AHEI-2010 (β, -0.05; 95% CI, -0.08 to -0.01), and ENI (β, -0.17; 95% CI, -0.29 to -0.06) scores, and added sugar intake (β, 0.02; 95% CI, 0.01-0.04) were each significantly associated with GrimAge2 in expected directions. In combined analyses, the aforementioned results with GrimAge2 were preserved with the association estimates for aMED and added sugar intake retaining their statistical significance.
UNASSIGNED: In this cross-sectional study, independent associations were observed for both healthy diet and added sugar intake with epigenetic age. To our knowledge, these are among the first findings to demonstrate associations between added sugar intake and epigenetic aging using second-generation epigenetic clocks and one of the first to extend analyses to a diverse population of Black and White women at midlife. Promoting diets aligned with chronic disease prevention recommendations and replete with antioxidant or anti-inflammatory and pro-epigenetic health nutrients while emphasizing low added sugar consumption may support slower cellular aging relative to chronological age, although longitudinal analyses are needed.