Abstract：
The Hippo pathway blocks epithelial-mesenchymal transition and metastasis in cancer mediated by the transcriptional coactivator YAP. In this issue of Science Signaling, Palamiuc et al. demonstrate that phosphatidylinositol 5-phosphate (PI5P) enhances Hippo pathway activation and that simultaneously the Hippo pathway initiates a positive feedback loop by inhibiting the conversion of PI5P into PIP2.
摘要：
Hippo途径阻断转录共激活因子YAP介导的上皮-间质转化和癌症转移。在这一期的科学信号,Palamiuc等人。证明磷脂酰肌醇5-磷酸（PI5P）增强Hippo途径的激活，同时Hippo途径通过抑制PI5P转化为PIP2启动正反馈回路。
