{Reference Type}: Journal Article
{Title}: A connection between phosphatidylinositol 5-phosphate and the Hippo pathway to prevent epithelial-mesenchymal transition in cancer.
{Author}: Hirsch E;Fantastico E;Prever L;Gulluni F;
{Journal}: Sci Signal
{Volume}: 17
{Issue}: 838
{Year}: 2024 May 28
{Factor}: 9.517
{DOI}: 10.1126/scisignal.adp3504
{Abstract}: The Hippo pathway blocks epithelial-mesenchymal transition and metastasis in cancer mediated by the transcriptional coactivator YAP. In this issue of Science Signaling, Palamiuc et al. demonstrate that phosphatidylinositol 5-phosphate (PI5P) enhances Hippo pathway activation and that simultaneously the Hippo pathway initiates a positive feedback loop by inhibiting the conversion of PI5P into PIP2.