%0 Journal Article
%T A connection between phosphatidylinositol 5-phosphate and the Hippo pathway to prevent epithelial-mesenchymal transition in cancer.
%A Hirsch E
%A Fantastico E
%A Prever L
%A Gulluni F
%J Sci Signal
%V 17
%N 838
%D 2024 May 28
%M 38805585
%F 9.517
%R 10.1126/scisignal.adp3504
%X The Hippo pathway blocks epithelial-mesenchymal transition and metastasis in cancer mediated by the transcriptional coactivator YAP. In this issue of Science Signaling, Palamiuc et al. demonstrate that phosphatidylinositol 5-phosphate (PI5P) enhances Hippo pathway activation and that simultaneously the Hippo pathway initiates a positive feedback loop by inhibiting the conversion of PI5P into PIP2.