PDF(Pubmed)
Abstract：
Basal cell carcinoma (BCC) is a common skin cancer type and affected individuals are known to be at risk of developing multiple consecutive tumours. Research into BCC multiplicity has, thus far, been challenging, due to a lack of national registration. This registry-based cohort study aimed to analyse the occurrence of multiple BCCs in Sweden, and risk factors for subsequent primary BCCs. Data regarding all histopathologically verified, primary BCC tumours in Sweden from 2004 to 2017 was extracted from the Swedish BCC Registry. Risk of developing a subsequent BCC in relation to person-related factors was estimated with Cox regression analysis. Cumulative risk of BCC development after 1 or 3 earlier BCCs was estimated. In total, 39.9% of individuals with a registered BCC had at least 2 registered tumours. The risk of developing a subsequent BCC increased significantly in males, older age, and with residence in southern Sweden. The cumulative 5-year risk of developing an additional BCC after first diagnosis was approximately 30% in males and 27% in females and increased after multiple previous BCCs. This study showed the cumulative risk of a subsequent BCC to increase with a history of multiple BCCs, indicating the need for clinical surveillance in these individuals.
摘要：
基底细胞癌（BCC）是一种常见的皮肤癌类型，已知受影响的个体有发展多个连续肿瘤的风险。对BCC多重性的研究，到目前为止，具有挑战性，由于缺乏国家注册。这项基于注册的队列研究旨在分析瑞典多种BCC的发生，以及后续主要BCC的风险因素。所有经组织病理学证实的数据，从瑞典BCC登记处提取了2004年至2017年瑞典的原发性BCC肿瘤。通过Cox回归分析估计与人相关因素相关的后续BCC的风险。估计了1或3个早期BCC后BCC发展的累积风险。总的来说,39.9％的注册BCC患者至少有2个注册肿瘤。在男性中，随后发生BCC的风险显着增加，年龄较大,并居住在瑞典南部。首次诊断后发生额外BCC的累积5年风险在男性中约为30％，在女性中约为27％，并且在先前多次BCC后增加。这项研究表明，随着多个BCC病史的增加，随后的BCC的累积风险增加。表明需要对这些个体进行临床监测。
