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Abstract：
BACKGROUND: The aging global population is experiencing escalating challenges related to cognitive deficits and dementia. This study explored the interplay between pulmonary function, physical activity, and cognitive function in older U.S. adults to identify modifiable risk factors for cognitive decline.
METHODS: Utilizing NHANES 2011-2012 data, we conducted a cross-sectional analysis of 729 participants aged ≥ 60 years. Cognitive function, peak expiratory flow (PEF), and physical activity were assessed. Weighted logistic regression and mediation analyses were employed to examine associations.
RESULTS: The sample size was 729 (weighted mean [SD] age, 67.1 [5.3] years; 53.6% female participants). Preliminary correlation analysis indicated a positive correlation between the global cognitive score and physical activity (β = 0.16; p < 0.001), recreational activity (β = 0.22; p < 0.001), and PEF in percent predicted (PEF%) (β = 0.18; p < 0.001). Compared to those with a PEF% >100%, the PEF% (80-100%) group (OR, 2.66; 95% CI, 1.34-5.29; p = 0.005) and PEF% <80% group (OR, 3.36; 95% CI, 1.67-6.76; p = 0.001) were significantly associated with higher cognitive deficits risk. Recreational activity meeting guidelines was linked to a lower risk of cognitive deficits (OR, 0.24; 95% CI, 0.10-0.57; p = 0.001). Mediation analysis demonstrated that PEF mediates the relationship between physical activity and cognitive function.
CONCLUSIONS: This study revealed significant associations between lower PEF, diminished physical activity, and increased cognitive deficits in elderly individuals. The results supported the hypothesis that pulmonary function may mediate the connection between activity and cognitive health, emphasizing the importance of respiratory health in cognitive aging. Recognizing these associations is crucial for clinical care and public health policy aiming to mitigate cognitive decline in aging populations. While these findings are intriguing, validation through longitudinal design studies is deemed necessary.
METHODS: Utilizing NHANES 2011-2012 data, we conducted a cross-sectional analysis of 729 participants aged ≥ 60 years. Cognitive function, peak expiratory flow (PEF), and physical activity were assessed. Weighted logistic regression and mediation analyses were employed to examine associations.
RESULTS: The sample size was 729 (weighted mean [SD] age, 67.1 [5.3] years; 53.6% female participants). Preliminary correlation analysis indicated a positive correlation between the global cognitive score and physical activity (β = 0.16; p < 0.001), recreational activity (β = 0.22; p < 0.001), and PEF in percent predicted (PEF%) (β = 0.18; p < 0.001). Compared to those with a PEF% >100%, the PEF% (80-100%) group (OR, 2.66; 95% CI, 1.34-5.29; p = 0.005) and PEF% <80% group (OR, 3.36; 95% CI, 1.67-6.76; p = 0.001) were significantly associated with higher cognitive deficits risk. Recreational activity meeting guidelines was linked to a lower risk of cognitive deficits (OR, 0.24; 95% CI, 0.10-0.57; p = 0.001). Mediation analysis demonstrated that PEF mediates the relationship between physical activity and cognitive function.
CONCLUSIONS: This study revealed significant associations between lower PEF, diminished physical activity, and increased cognitive deficits in elderly individuals. The results supported the hypothesis that pulmonary function may mediate the connection between activity and cognitive health, emphasizing the importance of respiratory health in cognitive aging. Recognizing these associations is crucial for clinical care and public health policy aiming to mitigate cognitive decline in aging populations. While these findings are intriguing, validation through longitudinal design studies is deemed necessary.
摘要：
背景：全球人口老龄化正在经历与认知缺陷和痴呆相关的不断升级的挑战。这项研究探讨了肺功能之间的相互作用，身体活动,和美国老年人的认知功能，以确定认知能力下降的可改变的危险因素。
方法：利用NHANES2011-2012年数据，我们对729名年龄≥60岁的参与者进行了横断面分析.认知功能,峰值呼气流量(PEF),和身体活动进行了评估。采用加权逻辑回归和中介分析来检查关联。
结果：样本量为729（加权平均值[SD]年龄，67.1[5.3]岁；53.6%的女性参与者)。初步相关分析显示整体认知评分与体力活动呈正相关(β=0.16;p<0.001),娱乐活动(β=0.22；p<0.001)，和预测的PEF百分比(PEF%)(β=0.18;p<0.001)。与PEF%>100%相比，PEF%(80-100%)组(OR，2.66;95%CI，1.34-5.29;p=0.005)和PEF%<80%组(OR，3.36；95%CI，1.67-6.76；p=0.001）与较高的认知障碍风险显着相关。娱乐活动会议指南与较低的认知缺陷风险(OR，0.24；95%CI，0.10-0.57；p=0.001）。中介分析表明，PEF介导了体力活动与认知功能之间的关系。
结论：这项研究揭示了较低PEF之间的显着关联，体力活动减少,老年人认知障碍增加。结果支持以下假设：肺功能可能介导活动与认知健康之间的联系，强调呼吸健康在认知老化中的重要性。认识到这些关联对于旨在减轻老龄化人群认知能力下降的临床护理和公共卫生政策至关重要。虽然这些发现很有趣,通过纵向设计研究进行验证是必要的。
方法：利用NHANES2011-2012年数据，我们对729名年龄≥60岁的参与者进行了横断面分析.认知功能,峰值呼气流量(PEF),和身体活动进行了评估。采用加权逻辑回归和中介分析来检查关联。
结果：样本量为729（加权平均值[SD]年龄，67.1[5.3]岁；53.6%的女性参与者)。初步相关分析显示整体认知评分与体力活动呈正相关(β=0.16;p<0.001),娱乐活动(β=0.22；p<0.001)，和预测的PEF百分比(PEF%)(β=0.18;p<0.001)。与PEF%>100%相比，PEF%(80-100%)组(OR，2.66;95%CI，1.34-5.29;p=0.005)和PEF%<80%组(OR，3.36；95%CI，1.67-6.76；p=0.001）与较高的认知障碍风险显着相关。娱乐活动会议指南与较低的认知缺陷风险(OR，0.24；95%CI，0.10-0.57；p=0.001）。中介分析表明，PEF介导了体力活动与认知功能之间的关系。
结论：这项研究揭示了较低PEF之间的显着关联，体力活动减少,老年人认知障碍增加。结果支持以下假设：肺功能可能介导活动与认知健康之间的联系，强调呼吸健康在认知老化中的重要性。认识到这些关联对于旨在减轻老龄化人群认知能力下降的临床护理和公共卫生政策至关重要。虽然这些发现很有趣,通过纵向设计研究进行验证是必要的。
