Abstract：
This investigation sought to ascertain whether orbital morphology could predict genuine metopic craniosynostosis (MCS). The study retrospectively analyzed preoperative three-dimensional computed tomography (3D-CT) scans of patients who underwent surgical correction for MCS. MCS severity was evaluated using the interfrontal angle (IFA). Orbital dysmorphology was assessed based on multiple angles, including supraorbital notches and nasion (SNS), infraorbital foramina and nasion (INI), zygomaticofrontal suture-supraorbital notch-dacryon (ZSD), and orbital long axis (OLA). Results were juxtaposed against age/gender-matched controls and individuals with non-synostotic metopic ridge (MR). The study included 177 patients: 68 MCS, 35 MR, and 74 control subjects. All orbital measurements exhibited significant differences across groups. IFA demonstrated a strong association with all orbital measurements, particularly SNS (B = 0.79, p < 0.001). SNS showed the highest area under the curve among orbital measurements (0.89). Using a 95% sensitivity threshold, the optimal diagnostic angle for SNS was 129.23° (specificity 54%, sensitivity 96%). These findings suggest a correlation between orbital dysmorphology and trigonocephaly severity. The observed dysmorphology manifested in a superomedially accentuated rotational pattern. Importantly, SNS angle predicted MCS, with an angle greater than 130° indicating <5% likelihood of MCS diagnosis. The simplicity of measuring SNS angle on any 3D-CT scan highlights its practical use for assisting with MCS diagnosis.
摘要：
这项研究旨在确定眼眶形态是否可以预测真正的异位颅骨融合（MCS）。该研究回顾性分析了接受MCS手术矫正的患者的术前三维计算机断层扫描（3D-CT）扫描。使用额间角（IFA）评估MCS严重程度。基于多个角度对轨道形态进行了评估，包括眶上凹口和鼻孔(SNS)，眶下孔眼和鼻孔（INI），接合性额叶缝合-眶上凹口-泪囊（ZSD），和轨道长轴（OLA）。结果与年龄/性别匹配的对照和非融合性异位脊（MR）的个体并列。该研究包括177名患者：68MCS，35MR,和74名对照受试者。所有眼眶测量结果均表现出各组间的显著差异。IFA证明了与所有轨道测量的强烈关联，特别是SNS（B=0.79，p<0.001）。SNS显示轨道测量中曲线下面积最高(0.89)。使用95%灵敏度阈值，SNS的最佳诊断角度为129.23°(特异性54%，灵敏度96%)。这些发现表明眼眶畸形和三角头严重程度之间存在相关性。观察到的形态学表现为超冠状的旋转模式。重要的是,SNS角度预测MCS，角度大于130°表示MCS诊断的可能性<5%。在任何3D-CT扫描上测量SNS角度的简单性突出了其用于辅助MCS诊断的实际用途。
