PDF(Pubmed)
Abstract：
Certain micronutrients exhibit immunomodulatory effects. However, no intervention has yet investigated the effect of individualized supplementation on the severity of upper respiratory tract infections (URIs). Therefore, we investigated whether a personalized supplementation moderates the incidence and severity of URI. Selenium, zinc, and vitamin D were measured in dried blood spots from 59 healthy participants. Accordingly, a personalized supplement was provided with or without the respective micronutrients. We used WURSS-21 questionnaires to assess the disease status. The blood values converged during the intervention and micronutrients no longer differed between treated and untreated volunteers at the end of the intervention period. The incidence and severity of the illness did not significantly differ between the groups. However, when analyzing the WURSS-21 scores by the intention to treat, the initially randomized treatment arm revealed a significantly higher score than the placebo arm. Upon acute administration, individualized combinations of selenium, zinc and vitamin D do not reduce the number, or contribute to a milder course of URIs. Therefore, supplementation in acute infectious situations seems questionable. Further studies must address the habitual diet in more detail, to better understand the impact of individual micronutrient status on the prevention of URI.
摘要：
某些微量营养素表现出免疫调节作用。然而,目前尚无干预措施研究个体化补充对上呼吸道感染(URI)严重程度的影响.因此,我们调查了个性化补充是否可以减轻URI的发生率和严重程度.硒,锌，对59名健康参与者的干血点进行了维生素D测定。因此，提供个性化的补充剂,有或没有各自的微量营养素.我们使用WURSS-21问卷评估疾病状态。在干预期间血液值趋同，并且在干预期结束时，治疗和未治疗的志愿者之间的微量营养素不再不同。两组之间疾病的发生率和严重程度没有显着差异。然而,当根据治疗意向分析WURSS-21得分时，最初随机分组治疗组的评分明显高于安慰剂组.急性给药时，硒的个性化组合，锌和维生素D不会减少数量，或有助于较温和的URI课程。因此,急性感染情况下的补充似乎值得怀疑。进一步的研究必须更详细地解决习惯性饮食，更好地了解个体微量营养素状况对预防URI的影响。
