PDF(Pubmed)
Abstract：
Antimicrobial drugs have made outstanding contributions to the treatment of pathogenic infections. However, the emergence of drug resistance continues to be a major threat to human health in recent years, and therefore, the search for novel antimicrobial drugs is particularly urgent. With a deeper understanding of microbial habits and drug resistance mechanisms, various creative strategies for the development of novel antibiotics have been proposed. Stilbenoids, characterized by a C6-C2-C6 carbon skeleton, have recently been widely recognized for their flexible antimicrobial roles. Here, we comprehensively summarize the mode of action of stilbenoids from the viewpoint of their direct antimicrobial properties, antibiofilm and antivirulence activities and their role in reversing drug resistance. This review will provide an important reference for the future development and research into the mechanisms of stilbenoids as antimicrobial agents.
摘要：
抗菌药物在治疗病原感染方面做出了突出贡献。然而,近年来，耐药性的出现仍然是人类健康的主要威胁，因此,寻找新型抗菌药物尤为迫切。随着对微生物习性和耐药机制的深入了解,已经提出了开发新型抗生素的各种创造性策略。Stilbenoids,以C6-C2-C6碳骨架为特征，最近因其灵活的抗菌作用而被广泛认可。这里,我们从直接抗菌性能的角度全面总结了二苯乙烯类的作用方式，抗生物膜和抗毒活性及其在逆转耐药性中的作用。本综述将为今后开发和研究二苯乙烯类抗菌药物的作用机制提供重要参考。
