PDF(Pubmed)
Abstract：
The goose astrovirus (GAstV), a key pathogen causing visceral gout and high mortality in geese, has spread widely in China, with frequent outbreaks in recent years. Outbreaks and transmissions of this virus have been reported across China, causing considerable economic losses to the goose industry worldwide, with losses exceeding tens of billions in China alone. However, there is still no effective prevention strategy against this virus. Therefore, continuous monitoring of the genetic diversity of dominant GAstV strains is crucial for developing targeted vaccines and appropriate therapeutics. As a crucial region for goose breeding in China, Hebei Province has previously lacked reports on the epidemiology of GAstV. Hence, investigating the epidemiology of GAstV in Hebei Province is highly important. From January 2019 to December 2021, 474 samples suspected of having a GAstV infection were collected in Hebei Province in this study. Through detailed histological observations, pathological examinations, virus isolation and identification, and genetic diversity analysis, we found that GAstV-2 has become the predominant circulating genotype. However, the presence of GAstV-1 and mixed infections cannot be ignored and should receive increased attention. The findings of this study not only deepened our understanding of GAstV in waterfowl in China but also provided scientific evidence for developing effective prevention and control measures, thereby promoting the healthy development of the goose industry in China.
摘要：
鹅星状病毒（GAstV），引起内脏痛风和鹅高死亡率的关键病原体，在中国广泛传播，近年来疫情频繁。据报道，这种病毒在中国各地爆发和传播，给全世界的鹅业造成了相当大的经济损失，仅在中国，损失就超过数百亿。然而,目前还没有有效的预防这种病毒的策略。因此,持续监测显性GAstV毒株的遗传多样性对于开发靶向疫苗和适当的治疗方法至关重要.作为我国鹅养殖的重要区域,河北省以前缺乏关于GAstV流行病学的报告。因此，调查GAstV在河北省的流行病学具有重要意义。从2019年1月至2021年12月，本研究在河北省收集了474个疑似GAstV感染的样本。通过详细的组织学观察，病理检查,病毒分离和鉴定，和遗传多样性分析，我们发现GAstV-2已成为主要的循环基因型.然而,GAstV-1和混合感染的存在不容忽视,应引起更多关注.本研究的发现不仅加深了我们对我国水禽GAstV的认识，而且为制定有效的防治措施提供了科学依据。从而促进我国鹅产业的健康发展。
