Abstract：
Immune-mediated vasculopathies occur secondary to infection or another noninfectious stimulus. Potential triggers include heterologous antigens including viruses, injected proteins and drugs; or auto-antigens including immunoglobulins or other endogenous proteins. Although these conditions are rare in horses, immune-mediated vasculopathies can cause considerable morbidity, with variable clinical signs depending on severity and organ system affected. Examples include purpura hemorrhagica, systemic lupus erythematosus, drug-induced vasculitis, paraneoplastic vasculitis, and idiopathic immune-mediated vasculitis. Diagnosis is presumptive or based on histopathology of skin biopsies if cutaneous signs are present. Treatment relies on removing the inciting cause, immunosuppression, and supportive care.
摘要：
免疫介导的血管病变继发于感染或其他非感染性刺激。潜在的触发因素包括异源抗原，包括病毒，注射的蛋白质和药物；或自身抗原，包括免疫球蛋白或其他内源性蛋白质。虽然这些情况在马匹中很少见，免疫介导的血管病变可以引起相当大的发病率，根据严重程度和受影响的器官系统，有不同的临床体征。例子包括出血性紫癜，系统性红斑狼疮,药物性血管炎,副肿瘤性血管炎,和特发性免疫介导性血管炎。如果存在皮肤体征，诊断是推定的或基于皮肤活检的组织病理学。治疗依赖于消除煽动原因，免疫抑制,和支持性护理。
