PDF(Pubmed)
Abstract：
OBJECTIVE: Dental hypersensitivity remains widespread, underscoring the need for materials that can effectively seal dental tubules. This study evaluated the potential of bioactive-glass-infused hydroxyethyl cellulose gels in this context.
METHODS: Five gels were synthesized, each containing 20% bioactive glass (specifically, 45S5, S53P4, Biomin F, and Biomin C), with an additional blank gel serving as a control. Subjected to two months of accelerated aging at 37 ± 2 °C, these gels were assessed for key properties: viscosity, water disintegration time, pH level, consistency, adhesion to glass, and element release capability.
RESULTS: Across the board, the gels facilitated the release of calcium, phosphate, and silicon ions, raising the pH from 9.00 ± 0.10 to 9.7 ± 0.0-a range conducive to remineralization. Dissolution in water occurred within 30-50 min post-application. Viscosity readings showed variability, with 45S5 reaching 6337 ± 24 mPa/s and Biomin F at 3269 ± 18 mPa/s after two months. Initial adhesion for the blank gel was measured at 0.27 ± 0.04 Pa, increasing to 0.73 ± 0.06 Pa for the others over time. Gels can release elements upon contact with water (Ca- Biomin C 104.8 ± 15.7 mg/L; Na- Biomin F 76.30 ± 11.44 mg/L; P- Biomin C 2.623 ± 0.393 mg/L; Si- 45S5-45.15 ± 6.77mg/L, F- Biomin F- 3.256 ± 0.651mg/L; Cl- Biomin C 135.5 ± 20.3 mg/L after 45 min).
CONCLUSIONS: These findings highlight the gels\' capacity to kickstart the remineralization process by delivering critical ions needed for enamel layer reconstruction. Further exploration in more dynamic, real-world conditions is recommended to fully ascertain their practical utility.
METHODS: Five gels were synthesized, each containing 20% bioactive glass (specifically, 45S5, S53P4, Biomin F, and Biomin C), with an additional blank gel serving as a control. Subjected to two months of accelerated aging at 37 ± 2 °C, these gels were assessed for key properties: viscosity, water disintegration time, pH level, consistency, adhesion to glass, and element release capability.
RESULTS: Across the board, the gels facilitated the release of calcium, phosphate, and silicon ions, raising the pH from 9.00 ± 0.10 to 9.7 ± 0.0-a range conducive to remineralization. Dissolution in water occurred within 30-50 min post-application. Viscosity readings showed variability, with 45S5 reaching 6337 ± 24 mPa/s and Biomin F at 3269 ± 18 mPa/s after two months. Initial adhesion for the blank gel was measured at 0.27 ± 0.04 Pa, increasing to 0.73 ± 0.06 Pa for the others over time. Gels can release elements upon contact with water (Ca- Biomin C 104.8 ± 15.7 mg/L; Na- Biomin F 76.30 ± 11.44 mg/L; P- Biomin C 2.623 ± 0.393 mg/L; Si- 45S5-45.15 ± 6.77mg/L, F- Biomin F- 3.256 ± 0.651mg/L; Cl- Biomin C 135.5 ± 20.3 mg/L after 45 min).
CONCLUSIONS: These findings highlight the gels\' capacity to kickstart the remineralization process by delivering critical ions needed for enamel layer reconstruction. Further exploration in more dynamic, real-world conditions is recommended to fully ascertain their practical utility.
摘要：
目的：牙齿过敏仍然普遍存在，强调需要材料，可以有效地密封牙小管。在这种情况下，这项研究评估了生物活性玻璃注入的羟乙基纤维素凝胶的潜力。
方法：合成了五种凝胶，每个含有20%的生物活性玻璃(特别是，45S5,S53P4,BiominF,和BiominC），用另外的空白凝胶作为对照。在37±2°C下加速老化两个月,评估了这些凝胶的关键特性：粘度，水崩解时间，pH值,一致性,对玻璃的附着力，和元素释放能力。
结果：全面，凝胶促进了钙的释放，磷酸盐,和硅离子，将pH值从9.00±0.10提高到9.7±0.0-一个有利于再矿化的范围。在施用后30-50分钟内发生在水中的溶解。粘度读数显示出变异性，两个月后45S5达到6337±24mPa/s，BiominF达到3269±18mPa/s。在0.27±0.04Pa下测量空白凝胶的初始粘附力，随着时间的推移，其他的增加到0.73±0.06Pa。凝胶与水接触后可释放元素(Ca-BiominC104.8±15.7mg/L;Na-BiominF76.30±11.44mg/L;P-BiominC2.623±0.393mg/L;Si-45S5-45.15±6.77mg/L,F-BiominF-3.256±0.651mg/L;Cl-BiominC135.5±20.3mg/L后45分钟)。
结论：这些发现强调了凝胶通过输送牙釉质层重建所需的关键离子来启动再矿化过程的能力。进一步探索更有活力，建议在实际条件下充分确定其实用性。
方法：合成了五种凝胶，每个含有20%的生物活性玻璃(特别是，45S5,S53P4,BiominF,和BiominC），用另外的空白凝胶作为对照。在37±2°C下加速老化两个月,评估了这些凝胶的关键特性：粘度，水崩解时间，pH值,一致性,对玻璃的附着力，和元素释放能力。
结果：全面，凝胶促进了钙的释放，磷酸盐,和硅离子，将pH值从9.00±0.10提高到9.7±0.0-一个有利于再矿化的范围。在施用后30-50分钟内发生在水中的溶解。粘度读数显示出变异性，两个月后45S5达到6337±24mPa/s，BiominF达到3269±18mPa/s。在0.27±0.04Pa下测量空白凝胶的初始粘附力，随着时间的推移，其他的增加到0.73±0.06Pa。凝胶与水接触后可释放元素(Ca-BiominC104.8±15.7mg/L;Na-BiominF76.30±11.44mg/L;P-BiominC2.623±0.393mg/L;Si-45S5-45.15±6.77mg/L,F-BiominF-3.256±0.651mg/L;Cl-BiominC135.5±20.3mg/L后45分钟)。
结论：这些发现强调了凝胶通过输送牙釉质层重建所需的关键离子来启动再矿化过程的能力。进一步探索更有活力，建议在实际条件下充分确定其实用性。
