PDF(Pubmed)
Abstract：
Mycoplasma pneumoniae, a notable pathogen behind respiratory infections, employs specialized proteins to adhere to the respiratory epithelium, an essential process for initiating infection. The role of glycosaminoglycans, especially heparan sulfate, is critical in facilitating pathogen-host interactions, presenting a strategic target for therapeutic intervention. In this study, we assembled a glycan library comprising heparin, its oligosaccharide derivatives, and a variety of marine-derived sulfated glycans to screen the potential inhibitors for the pathogen-host interactions. By using Surface Plasmon Resonance spectroscopy, we evaluated the library\'s efficacy in inhibiting the interaction between M. pneumoniae adhesion proteins and heparin. Our findings offer a promising avenue for developing novel therapeutic strategies against M. pneumoniae infections.
摘要：
肺炎支原体,呼吸道感染背后的一个值得注意的病原体，使用专门的蛋白质粘附在呼吸道上皮上，启动感染的基本过程。糖胺聚糖的作用，尤其是硫酸乙酰肝素，在促进病原体-宿主相互作用方面至关重要，提出了治疗干预的战略目标。在这项研究中,我们组装了一个包含肝素的聚糖文库，其寡糖衍生物，和各种海洋来源的硫酸化聚糖来筛选病原体-宿主相互作用的潜在抑制剂。通过使用表面等离子体共振光谱，我们评估了文库抑制肺炎支原体粘附蛋白和肝素之间相互作用的功效。我们的发现为开发针对肺炎支原体感染的新型治疗策略提供了有希望的途径。
