PDF(Pubmed)
Abstract：
Marine-derived Penicillium fungi are productive sources of structurally unique and diverse bioactive secondary metabolites, representing a hot topic in natural product research. This review describes structural diversity, bioactivities and statistical research of 452 new natural products from marine-derived Penicillium fungi covering 2021 to 2023. Sediments are the main sources of marine-derived Penicillium fungi for producing nearly 56% new natural products. Polyketides, alkaloids, and terpenoids displayed diverse biological activities and are the major contributors to antibacterial activity, cytotoxicity, anti-inflammatory and enzyme inhibitory capacities. Polyketides had higher proportions of new bioactive compounds in new compounds than other chemical classes. The characteristics of studies in recent years are presented.
摘要：
海洋衍生的青霉真菌是结构独特和多样的生物活性次生代谢产物的生产来源，代表了天然产物研究的热门话题。这篇综述描述了结构多样性，2021年至2023年海洋衍生的青霉真菌452种新天然产物的生物活性和统计研究。沉积物是海洋衍生的青霉真菌的主要来源，可产生近56％的新天然产物。聚酮化合物,生物碱，和萜类化合物表现出多种生物活性，是抗菌活性的主要贡献者，细胞毒性，抗炎和酶抑制能力。聚酮化合物在新化合物中的新生物活性化合物的比例高于其他化学类别。介绍了近年来的研究特点。
