%0 Journal Article
%T Novel Bioactive Natural Products from Marine-Derived Penicillium Fungi: A Review (2021-2023).
%A Lv F
%A Zeng Y
%J Mar Drugs
%V 22
%N 5
%D 2024 Apr 23
%M 38786582
%F 6.085
%R 10.3390/md22050191
%X Marine-derived Penicillium fungi are productive sources of structurally unique and diverse bioactive secondary metabolites, representing a hot topic in natural product research. This review describes structural diversity, bioactivities and statistical research of 452 new natural products from marine-derived Penicillium fungi covering 2021 to 2023. Sediments are the main sources of marine-derived Penicillium fungi for producing nearly 56% new natural products. Polyketides, alkaloids, and terpenoids displayed diverse biological activities and are the major contributors to antibacterial activity, cytotoxicity, anti-inflammatory and enzyme inhibitory capacities. Polyketides had higher proportions of new bioactive compounds in new compounds than other chemical classes. The characteristics of studies in recent years are presented.