PDF(Pubmed)
Abstract：
This article examines the involvement of the brain-derived neurotrophic factor (BDNF) in the control of nociception and pain. BDNF, a neurotrophin known for its essential role in neuronal survival and plasticity, has garnered significant attention for its potential implications as a modulator of synaptic transmission. This comprehensive review aims to provide insights into the multifaceted interactions between BDNF and pain pathways, encompassing both physiological and pathological pain conditions. I delve into the molecular mechanisms underlying BDNF\'s involvement in pain processing and discuss potential therapeutic applications of BDNF and its mimetics in managing pain. Furthermore, I highlight recent advancements and challenges in translating BDNF-related research into clinical practice.
摘要：
本文研究了脑源性神经营养因子（BDNF）在控制伤害感受和疼痛中的作用。BDNF,一种神经营养蛋白，以其在神经元存活和可塑性中的重要作用而闻名，由于其作为突触传递调节剂的潜在含义而引起了极大的关注。这篇全面的综述旨在提供对BDNF和疼痛通路之间多方面相互作用的见解。包括生理和病理疼痛条件。我深入研究了BDNF参与疼痛处理的分子机制，并讨论了BDNF及其模拟物在管理疼痛方面的潜在治疗应用。此外，我强调在将BDNF相关研究转化为临床实践方面的最新进展和挑战。
