PDF(Pubmed)
Abstract：
Squamous cell carcinoma (SCC) stands as the second most prevalent skin cancer in dogs, primarily attributed to UV radiation exposure. Affected areas typically include regions with sparse hair and pale or depigmented skin. The significance of spontaneous canine cutaneous SCC as a model for its human counterpart is underscored by its resemblance. This study assesses the expression of key markers-Epidermal Growth Factor Receptor (EGFR), Cyclooxygenase-2 (Cox-2), and Ki-67-in canine cutaneous SCC. Our objective is to investigate the association between their expression levels and classical clinicopathological parameters, unraveling the intricate relationships among these molecular markers. In our retrospective analysis of 37 cases, EGFR overexpression manifested in 43.2% of cases, while Cox-2 exhibited overexpression in 97.3%. The EGFR, Cox-2 overexpression, and Ki-67 proliferation indices, estimated through immunohistochemistry, displayed a significant association with the histological grade, but only EGFR labeling is associated with the presence of lymphovascular emboli. The Ki-67 labeling index expression exhibited an association with EGFR and Cox-2. These findings propose that EGFR, Cox-2, and Ki-67 hold promise as valuable markers in canine SCC. EGFR, Cox-2, and Ki-67 may serve as indicators of disease progression, offering insights into the malignancy of a lesion. The implications extend to the potential therapeutic targeting of EGFR and Cox-2 in managing canine SCC. Further exploration of these insights is warranted due to their translational relevance and the development of targeted interventions in the context of canine SCC.
摘要：
鳞状细胞癌（SCC）是狗中第二大最常见的皮肤癌，主要归因于紫外线辐射暴露。受影响的区域通常包括具有稀疏毛发和苍白或色素减退的皮肤的区域。自发性犬皮肤SCC作为其人类对应物模型的重要性由其相似性强调。这项研究评估了关键标志物-表皮生长因子受体（EGFR）的表达，环氧合酶-2(Cox-2),和Ki-67-在犬皮肤SCC中。我们的目的是研究它们的表达水平与经典临床病理参数之间的关系，解开这些分子标记之间复杂的关系。在我们对37例病例的回顾性分析中，在43.2%的病例中表现为EGFR过度表达,而Cox-2在97.3%表现出过表达。EGFR,Cox-2过表达,和Ki-67增殖指数，通过免疫组织化学估计，与组织学分级有显著关联，但只有EGFR标记与淋巴管栓塞的存在有关。Ki-67标记指数表达与EGFR和Cox-2相关。这些发现表明EGFR，Cox-2和Ki-67有望成为犬SCC的有价值标志物。EGFR,Cox-2和Ki-67可以作为疾病进展的指标，提供对病变恶性的见解。其含义扩展到EGFR和Cox-2在管理犬SCC中的潜在治疗靶向。由于它们的翻译相关性以及在犬SCC背景下针对性干预措施的发展，因此需要进一步探索这些见解。
