METHODS: We conducted a hospital-based case-control study at Viet Duc University Hospital in Hanoi, Vietnam. Cases consisted of children with brain tumors aged 0-14 years old admitted to the hospital from January 2020 to July 2022 while the controls were age and sex-matched hospitalized children diagnosed with head trauma. Perinatal characteristics were abstracted from hospital medical records and maternal medical, behavioral, and sociodemographic factors were collected through in-person interviews. Conditional logistic regression models were used to examine maternal and perinatal factors associated with childhood brain tumors.
RESULTS: The study sample included 220 children (110 cases and 110 controls) whose average age was 8.9 years and 41.8% were girls. Children born to mothers aged greater than 30 years at the time of the child\'s birth had a higher risk of childhood brain tumors compared to those born to mothers aged from 18 to 30 years old (OR = 2.55; 95% CI: 1.13-5.75). Additionally low maternal body mass index prior to the current pregnancy of <18.5 kg/m2 significantly increased the odds of having a child with a brain tumor in relation to normal maternal body mass index from 18.5-22.9 kg/m2 (OR = 3.19; 95% CI: 1.36 - 7.50).
CONCLUSIONS: Advanced maternal age and being markedly underweight were associated with an increased odds of having a child with a brain tumor. A population-based study with larger sample size is needed to confirm and extend the present findings.
方法:我们在河内的VietDuc大学医院进行了一项基于医院的病例对照研究,越南。病例包括2020年1月至2022年7月入院的0-14岁脑肿瘤儿童,而对照组是年龄和性别匹配的住院儿童,诊断为头部创伤。从医院病历和产妇医疗中提取围产期特征,行为,社会人口统计学因素是通过面对面访谈收集的。使用条件逻辑回归模型来检查与儿童脑肿瘤相关的母体和围产期因素。
结果:研究样本包括220名儿童(110例和110例对照),平均年龄为8.9岁,其中41.8%为女孩。与18至30岁的母亲出生的孩子相比,孩子出生时年龄大于30岁的母亲所生的孩子患儿童脑肿瘤的风险更高(OR=2.55;95%CI:1.13-5.75)。此外,当前妊娠前母亲体重指数<18.5kg/m2,与正常母亲体重指数相比,母亲患脑肿瘤的几率从18.5-22.9kg/m2显著增加(OR=3.19;95%CI:1.36-7.50)。
结论:高龄产妇年龄和体重明显不足与孩子患脑肿瘤的几率增加有关。需要以更大的样本量为基础的研究来确认和扩展目前的发现。