PDF(Pubmed)
Abstract：
BACKGROUND: Numerous meta-analyses have explored the association between the triglyceride-glucose (TyG) index and diverse health outcomes, yet the comprehensive assessment of the scope, validity, and quality of this evidence remains incomplete. Our aim was to systematically review and synthesise existing meta-analyses of TyG index and health outcomes and to assess the quality of the evidence.
METHODS: A thorough search of PubMed, EMBASE, and Web of Science databases was conducted from their inception through to 8 April 2024. We assessed the quality of reviews using A Measurement Tool to Assess Systematic Reviews (AMSTAR) and the certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. This study was registered with PROSPERO (CRD: 42024518587).
RESULTS: Overall, a total of 95 associations from 29 meta-analyses were included, investigating associations between TyG index and 30 health outcomes. Of these, 83 (87.4%) associations were statistically significant (P < 0.05) according to the random effects model. Based on the AMSTAR tool, 16 (55.2%) meta-analyses were high quality and none was low quality. The certainty of the evidence, assessed by the GRADE framework, showed that 6 (6.3%) associations were supported by moderate-quality evidence. When compared with the lowest category of the TyG index, the risk of contrast-induced nephropathy (CIN) [relative risk (RR) = 2.25, 95%CI 1.82, 2.77], the risk of stroke in patients with diabetes mellitus (RR = 1.26, 95%CI 1.18, 1.33) or with acute coronary syndrome disease (RR = 1.56, 95%CI 1.06, 2.28), the prognosis of coronary artery disease (CAD)-non-fatal MI (RR = 2.02, 95%CI 1.32, 3.10), and the severity of CAD including coronary artery stenosis (RR = 3.49, 95%CI 1.71, 7.12) and multi-vessel CAD (RR = 2.33, 95%CI 1.59, 3.42) increased with high TyG index.
CONCLUSIONS: We found that the TyG index was positively associated with many diseases including the risk of CIN and stroke, the prognosis of CAD, and the severity of CAD which were supported by moderate-quality evidence. TyG index might be useful to identify people at high-risk for developing these diseases.
METHODS: A thorough search of PubMed, EMBASE, and Web of Science databases was conducted from their inception through to 8 April 2024. We assessed the quality of reviews using A Measurement Tool to Assess Systematic Reviews (AMSTAR) and the certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. This study was registered with PROSPERO (CRD: 42024518587).
RESULTS: Overall, a total of 95 associations from 29 meta-analyses were included, investigating associations between TyG index and 30 health outcomes. Of these, 83 (87.4%) associations were statistically significant (P < 0.05) according to the random effects model. Based on the AMSTAR tool, 16 (55.2%) meta-analyses were high quality and none was low quality. The certainty of the evidence, assessed by the GRADE framework, showed that 6 (6.3%) associations were supported by moderate-quality evidence. When compared with the lowest category of the TyG index, the risk of contrast-induced nephropathy (CIN) [relative risk (RR) = 2.25, 95%CI 1.82, 2.77], the risk of stroke in patients with diabetes mellitus (RR = 1.26, 95%CI 1.18, 1.33) or with acute coronary syndrome disease (RR = 1.56, 95%CI 1.06, 2.28), the prognosis of coronary artery disease (CAD)-non-fatal MI (RR = 2.02, 95%CI 1.32, 3.10), and the severity of CAD including coronary artery stenosis (RR = 3.49, 95%CI 1.71, 7.12) and multi-vessel CAD (RR = 2.33, 95%CI 1.59, 3.42) increased with high TyG index.
CONCLUSIONS: We found that the TyG index was positively associated with many diseases including the risk of CIN and stroke, the prognosis of CAD, and the severity of CAD which were supported by moderate-quality evidence. TyG index might be useful to identify people at high-risk for developing these diseases.
摘要：
背景：许多荟萃分析已经探索了甘油三酯-葡萄糖（TyG）指数与不同健康结果之间的关联，然而，对范围的全面评估，有效性，并且这些证据的质量仍然不完整。我们的目的是系统地审查和综合现有的TyG指数和健康结果的荟萃分析，并评估证据的质量。
方法：彻底搜索PubMed，EMBASE,和WebofScience数据库从成立到2024年4月8日进行。我们使用评估系统评论的测量工具（AMSTAR）评估评论的质量，并使用建议分级评估证据的确定性。评估,开发和评估（等级）系统。本研究在PROSPERO注册(CRD:42024518587)。
结果：总体而言，共纳入来自29个荟萃分析的95个关联，调查TyG指数与30项健康结果之间的关联。其中,根据随机效应模型，83（87.4％）个关联具有统计学意义（P<0.05）。基于AMSTAR工具，16项(55.2%)荟萃分析是高质量的，没有一项是低质量的。证据的确定性,由等级框架评估，显示有6个（6.3％）关联得到中等质量证据的支持。与TyG指数的最低类别相比，对比剂肾病（CIN）的风险[相对风险（RR）=2.25，95CI1.82，2.77]，糖尿病患者(RR=1.26,95CI1.18,1.33)或急性冠脉综合征患者(RR=1.56,95CI1.06,2.28)的卒中风险,冠状动脉疾病（CAD）-非致死性MI的预后（RR=2.02，95CI1.32，3.10），冠状动脉狭窄（RR=3.49，95CI1.71，7.12）和多血管CAD（RR=2.33，95CI1.59，3.42）的严重程度随高TyG指数而增加。
结论：我们发现TyG指数与许多疾病呈正相关，包括CIN和卒中的风险，CAD的预后，和CAD的严重程度得到中等质量证据的支持。TyG指数可能有助于识别患有这些疾病的高风险人群。
方法：彻底搜索PubMed，EMBASE,和WebofScience数据库从成立到2024年4月8日进行。我们使用评估系统评论的测量工具（AMSTAR）评估评论的质量，并使用建议分级评估证据的确定性。评估,开发和评估（等级）系统。本研究在PROSPERO注册(CRD:42024518587)。
结果：总体而言，共纳入来自29个荟萃分析的95个关联，调查TyG指数与30项健康结果之间的关联。其中,根据随机效应模型，83（87.4％）个关联具有统计学意义（P<0.05）。基于AMSTAR工具，16项(55.2%)荟萃分析是高质量的，没有一项是低质量的。证据的确定性,由等级框架评估，显示有6个（6.3％）关联得到中等质量证据的支持。与TyG指数的最低类别相比，对比剂肾病（CIN）的风险[相对风险（RR）=2.25，95CI1.82，2.77]，糖尿病患者(RR=1.26,95CI1.18,1.33)或急性冠脉综合征患者(RR=1.56,95CI1.06,2.28)的卒中风险,冠状动脉疾病（CAD）-非致死性MI的预后（RR=2.02，95CI1.32，3.10），冠状动脉狭窄（RR=3.49，95CI1.71，7.12）和多血管CAD（RR=2.33，95CI1.59，3.42）的严重程度随高TyG指数而增加。
结论：我们发现TyG指数与许多疾病呈正相关，包括CIN和卒中的风险，CAD的预后，和CAD的严重程度得到中等质量证据的支持。TyG指数可能有助于识别患有这些疾病的高风险人群。
