Abstract：
Although intraductal oncocytic papillary neoplasm (IOPN) was considered distinct from the intraductal papillary neoplasm of the pancreas, the oncocytic histologic type remained as a subtype of intraductal papillary neoplasms of the bile duct (IPNBs) with gastric, intestinal, and pancreatobiliary types based on the fifth edition of the WHO classification. To test the characteristics of the oncocytic type of IPNBs, the histopathologic, immunohistochemical (Hep Par-1 and CD117), and clinical characteristics of 13 oncocytic type were compared with 114 others (15 gastric, 39 pancreatobiliary, and 60 intestinal) IPNB types. The oncocytic type, which occupied about 9% of IPNBs, was more frequent in females (p < 0.05) and larger (mean, 5.3 vs. 3.6 cm; p < 0.002) than other IPNB types. Immunohistochemically, the oncocytic type had more frequent combined Hep Par-1 and CD117 expression than other IPNB types (all p < 0.05). The recurrence-free survival rate for patients with the oncocytic type (5-year survival, 100%) was significantly higher (p = 0.015) than for those with other histologic types (59.9%). The oncocytic type had distinct histopathologic, immunohistochemical, and survival outcomes from other IPNBs. Therefore, it can be separated from other IPNB types and classified as one independent entity, similar to IOPN of the pancreas.
摘要：
尽管导管内嗜酸细胞乳头状肿瘤（IOPN）被认为与胰腺的导管内乳头状肿瘤不同，嗜酸细胞组织学类型仍然是胆管导管内乳头状肿瘤（IPNBs）的亚型，肠,和基于WHO分类的第五版的胰胆管类型。为了测试嗜酸性细胞型IPNBs的特征，组织病理学，免疫组织化学（HepPar-1和CD117），并将13例嗜酸细胞型的临床特征与114例其他类型的临床特征进行了比较（15例胃，39胰胆管，和60种肠）IPNB类型。嗜酸细胞型，占据了约9%的IPNB，在女性中更常见(p<0.05)和更大(平均值，5.3vs.3.6厘米；p<0.002）比其他IPNB类型。免疫组织化学，与其他IPNB类型相比，嗜酸细胞型的HepPar-1和CD117表达更频繁和组合，(均p<0.05)。嗜酸细胞型患者的无复发生存率（5年生存率，100％）显着高于（p=0.015）其他组织学类型的患者（59.9％）。嗜酸细胞型具有明显的组织病理学，免疫组织化学，以及其他IPNB的生存结果。因此,它可以与其他IPNB类型分离，并归类为一个独立的实体，与胰腺的IOPN相似。
