PDF(Pubmed)
Abstract：
In eukaryotic cells, the nuclear envelope (NE) is a membrane partition between the nucleus and the cytoplasm to compartmentalize nuclear contents. It plays an important role in facilitating nuclear functions including transcription, DNA replication and repair. In mammalian cells, the NE breaks down and then reforms during cell division, and in interphase it is restored shortly after the NE rupture induced by mechanical force. In this way, the partitioning effect is regulated through dynamic processes throughout the cell cycle. A failure in rebuilding the NE structure triggers the mixing of nuclear and cytoplasmic contents, leading to catastrophic consequences for the nuclear functions. Whereas the precise details of molecular mechanisms for NE reformation during cell division and NE restoration in interphase are still being investigated, here, we mostly focus on mammalian cells to describe key aspects that have been identified and to discuss the crosstalk between them.
摘要：
在真核细胞中,核膜（NE）是细胞核和细胞质之间的膜分区，以分隔核内容物。它在促进核功能包括转录中起着重要作用，DNA复制和修复。在哺乳动物细胞中,NE在细胞分裂过程中分解然后重新形成，在中间阶段，它在机械力引起的NE破裂后不久就恢复了。这样,分配效应通过整个细胞周期的动态过程来调节。重建NE结构的失败会触发细胞核和细胞质内容物的混合，导致核功能的灾难性后果。尽管细胞分裂过程中NE重整和间期NE恢复的分子机制的精确细节仍在研究中，在这里，我们主要关注哺乳动物细胞来描述已经确定的关键方面，并讨论它们之间的串扰。
