PDF(Pubmed)
Abstract：
Hypervirulent K. pneumoniae infection has been raising worldwide and is one of the major causes of community-acquired pyogenic liver abscess. We described a case report of pyogenic liver abscess caused by an atypical hypervirulent (non-hypermucoviscous) K. pneumoniae K1 ST23 in a diabetic Asian patient who resided in Mexico. The susceptibility to antimicrobials, pathogenicity, molecular and genomic analysis were determined. A man from Guangdong (China) with a recent diagnosis of diabetes mellitus was admitted to the hospital, and he denied traveling in the last 3 months. A computed tomography revealed a right lobe liver abscess. On the third day after admission a Klebsiella pneumoniae isolate (14652) was obtained. The isolate corresponded to a susceptible K. pneumoniae with capsular type K1 and ST23 (CG23) and exhibited a non-hypermucoviscous phenotype. The isolate 14652 was genetically related to the globally distributed lineage ST23-KL1. This study describes the first case in Mexico of K. pneumoniae capsular type K1 and ST23 with an atypical hypervirulent phenotype.
摘要：
高毒力肺炎克雷伯菌感染在全球范围内呈上升趋势，是社区获得性化脓性肝脓肿的主要原因之一。我们描述了一例在墨西哥居住的亚洲糖尿病患者中，由非典型高毒力（非高粘膜粘性）肺炎克雷伯菌K1ST23引起的化脓性肝脓肿的病例报告。对抗菌药物的敏感性，致病性，确定了分子和基因组分析。一名来自广东(中国)最近诊断为糖尿病的男子入院治疗,他否认在过去的三个月里旅行。计算机断层扫描显示右叶肝脓肿。在入院后的第三天,获得肺炎克雷伯菌分离物(14652)。该分离株对应于具有荚膜型K1和ST23（CG23）的易感肺炎克雷伯菌，并表现出非高粘膜粘性表型。分离物14652在遗传上与全球分布的谱系ST23-KL1相关。这项研究描述了墨西哥首例肺炎克雷伯菌荚膜型K1和ST23，具有非典型高毒力表型。
