OBJECTIVE: Assess NMIs\' impact on frail and pre-frail older adults across diverse outcomes.
METHODS: A systematic review and meta-analysis of 13 studies (2012-2023) evaluated NMIs\' effects on physical, dietary, psychological, and frailty aspects. Literature quality was assessed, and data analyzed with Review Manager 5.3.
RESULTS: A total of 13 studies involving participants were included in the analysis. Participants numbered 968, with the intervention group averaging 77.05±0.77 years and the control group 78.75±0.8 years. Compared to control groups,NMIs significantly increased body weight (SMD = 0.26, P = 0.03) and improved gait speed (SMD = 0.18, P = 0.03). Protein intake showed significance for interventions≤12 weeks (SMD = 1.04, P < 0.001). No significant differences in energy intake (SMD = 0.20, P = 0.60), but >12 weeks NMIs reduced energy intake (SMD = -0.73, P = 0.006). No significant differences in depressive symptoms, frailty scores, BMI, TUG, Handgrip Strength, or SPPB.
CONCLUSIONS: This meta-analysis underscores NMIs\' potential benefits for frail and pre-frail older adults. Personalized, multidimensional interventions are recommended despite study limitations, emphasizing extended interventions and diverse assessments for holistic care.
目的:评估NMI对体弱和体弱前老年人的不同结局的影响。
方法:对13项研究(2012-2023年)的系统评价和荟萃分析评估了NMI对身体,饮食,心理,和脆弱的方面。评估文献质量,并使用ReviewManager5.3进行数据分析。
结果:共有13项涉及参与者的研究纳入分析。参与者人数为968,干预组平均为77.05±0.77年,对照组平均为78.75±0.8年。与对照组相比,NMIs显着增加体重(SMD=0.26,P=0.03)并改善步态速度(SMD=0.18,P=0.03)。蛋白质摄入量对≤12周的干预有显著性意义(SMD=1.04,P<0.001)。能量摄入无显著差异(SMD=0.20,P=0.60),但>12周NMI降低能量摄入(SMD=-0.73,P=0.006)。抑郁症状没有显着差异,脆弱的分数,BMI,TUG,手柄力量,或SPPB。
结论:这项荟萃分析强调了NMI对体弱和体弱前老年人的潜在益处。个性化,尽管研究有局限性,但仍建议采取多维干预措施,强调扩大干预措施和全面护理的多样化评估。