Abstract：
BACKGROUND: Frailty, a prevalent geriatric syndrome, presents challenges exacerbated by malnutrition. Nutritional Management Interventions (NMIs) offer hope in frailty reversal, necessitating exploration of their multi-dimensional outcomes.
OBJECTIVE: Assess NMIs\' impact on frail and pre-frail older adults across diverse outcomes.
METHODS: A systematic review and meta-analysis of 13 studies (2012-2023) evaluated NMIs\' effects on physical, dietary, psychological, and frailty aspects. Literature quality was assessed, and data analyzed with Review Manager 5.3.
RESULTS: A total of 13 studies involving participants were included in the analysis. Participants numbered 968, with the intervention group averaging 77.05±0.77 years and the control group 78.75±0.8 years. Compared to control groups,NMIs significantly increased body weight (SMD = 0.26, P = 0.03) and improved gait speed (SMD = 0.18, P = 0.03). Protein intake showed significance for interventions≤12 weeks (SMD = 1.04, P < 0.001). No significant differences in energy intake (SMD = 0.20, P = 0.60), but >12 weeks NMIs reduced energy intake (SMD = -0.73, P = 0.006). No significant differences in depressive symptoms, frailty scores, BMI, TUG, Handgrip Strength, or SPPB.
CONCLUSIONS: This meta-analysis underscores NMIs\' potential benefits for frail and pre-frail older adults. Personalized, multidimensional interventions are recommended despite study limitations, emphasizing extended interventions and diverse assessments for holistic care.
OBJECTIVE: Assess NMIs\' impact on frail and pre-frail older adults across diverse outcomes.
METHODS: A systematic review and meta-analysis of 13 studies (2012-2023) evaluated NMIs\' effects on physical, dietary, psychological, and frailty aspects. Literature quality was assessed, and data analyzed with Review Manager 5.3.
RESULTS: A total of 13 studies involving participants were included in the analysis. Participants numbered 968, with the intervention group averaging 77.05±0.77 years and the control group 78.75±0.8 years. Compared to control groups,NMIs significantly increased body weight (SMD = 0.26, P = 0.03) and improved gait speed (SMD = 0.18, P = 0.03). Protein intake showed significance for interventions≤12 weeks (SMD = 1.04, P < 0.001). No significant differences in energy intake (SMD = 0.20, P = 0.60), but >12 weeks NMIs reduced energy intake (SMD = -0.73, P = 0.006). No significant differences in depressive symptoms, frailty scores, BMI, TUG, Handgrip Strength, or SPPB.
CONCLUSIONS: This meta-analysis underscores NMIs\' potential benefits for frail and pre-frail older adults. Personalized, multidimensional interventions are recommended despite study limitations, emphasizing extended interventions and diverse assessments for holistic care.
摘要：
背景：脆弱，一种普遍的老年综合征，提出了因营养不良而加剧的挑战。营养管理干预措施(NMI)为虚弱逆转提供了希望，有必要探索它们的多维结果。
目的：评估NMI对体弱和体弱前老年人的不同结局的影响。
方法：对13项研究（2012-2023年）的系统评价和荟萃分析评估了NMI对身体，饮食，心理,和脆弱的方面。评估文献质量，并使用ReviewManager5.3进行数据分析。
结果：共有13项涉及参与者的研究纳入分析。参与者人数为968，干预组平均为77.05±0.77年，对照组平均为78.75±0.8年。与对照组相比，NMIs显着增加体重（SMD=0.26，P=0.03）并改善步态速度（SMD=0.18，P=0.03）。蛋白质摄入量对≤12周的干预有显著性意义(SMD=1.04,P<0.001)。能量摄入无显著差异(SMD=0.20,P=0.60),但>12周NMI降低能量摄入（SMD=-0.73，P=0.006）。抑郁症状没有显着差异，脆弱的分数，BMI,TUG,手柄力量,或SPPB。
结论：这项荟萃分析强调了NMI对体弱和体弱前老年人的潜在益处。个性化,尽管研究有局限性，但仍建议采取多维干预措施，强调扩大干预措施和全面护理的多样化评估。
目的：评估NMI对体弱和体弱前老年人的不同结局的影响。
方法：对13项研究（2012-2023年）的系统评价和荟萃分析评估了NMI对身体，饮食，心理,和脆弱的方面。评估文献质量，并使用ReviewManager5.3进行数据分析。
结果：共有13项涉及参与者的研究纳入分析。参与者人数为968，干预组平均为77.05±0.77年，对照组平均为78.75±0.8年。与对照组相比，NMIs显着增加体重（SMD=0.26，P=0.03）并改善步态速度（SMD=0.18，P=0.03）。蛋白质摄入量对≤12周的干预有显著性意义(SMD=1.04,P<0.001)。能量摄入无显著差异(SMD=0.20,P=0.60),但>12周NMI降低能量摄入（SMD=-0.73，P=0.006）。抑郁症状没有显着差异，脆弱的分数，BMI,TUG,手柄力量,或SPPB。
结论：这项荟萃分析强调了NMI对体弱和体弱前老年人的潜在益处。个性化,尽管研究有局限性，但仍建议采取多维干预措施，强调扩大干预措施和全面护理的多样化评估。
