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Abstract：
OBJECTIVE: The aim of the study was to compare the epidemiology and clinical profiles of hospital admissions in a single Brazilian Hepatology Unit from the period 2014-2017 to 2019-2022.
METHODS: A retrospective analysis of hospital database from the abovementioned periods was done. The study included patients over the age of 18 years who were hospitalized due to complications of diseases such as viral hepatitis, alcoholic disease, nonalcoholic fatty liver disease, and autoimmune liver and drug-induced hepatitis.
RESULTS: In both study periods, middle-aged males were predominant and were younger than females. In the first period (2014-2017), hepatitis C (33.5%) was the most prevalent cause of admission, followed by alcoholic liver disease (31.7%). In the second period (2019-2022), nonalcoholic fatty liver disease (38%) and alcoholic liver disease (27.6%) were the most frequent causes of admission. No changes were observed in the proportion of alcoholic liver disease or drug-induced hepatitis in both study periods. The prevalence of viral hepatitis decreased in both genders, with hepatitis C decreasing from 32.4 to 9.7% for males and 35.4 to 10.8% for females, and OR=0.2; 95%CI 0.1-0.3 for both males and females. Similarly, the prevalence of hepatitis B decreased from 19.1 to 8.1% and OR=0.3; 95%CI 0.2-0.5 for males and 8.2 to 3.7% and OR=0.4; 95%CI 0.1-0.9 for females. The prevalence of autoimmune liver diseases increased only in males, from 2.1 to 5.9% and OR=2.9; 95%CI 1.2-6.6.
CONCLUSIONS: Over the past 4 years, there has been a shift in hospital admission profile at a Brazilian Hepatology Unit, with a decrease in viral hepatitis and an increase in autoimmune diseases and nonalcoholic fatty liver disease. Males were more affected at younger ages than females. Furthermore, ascites was the most prevalent cause of complications in both periods analyzed.
METHODS: A retrospective analysis of hospital database from the abovementioned periods was done. The study included patients over the age of 18 years who were hospitalized due to complications of diseases such as viral hepatitis, alcoholic disease, nonalcoholic fatty liver disease, and autoimmune liver and drug-induced hepatitis.
RESULTS: In both study periods, middle-aged males were predominant and were younger than females. In the first period (2014-2017), hepatitis C (33.5%) was the most prevalent cause of admission, followed by alcoholic liver disease (31.7%). In the second period (2019-2022), nonalcoholic fatty liver disease (38%) and alcoholic liver disease (27.6%) were the most frequent causes of admission. No changes were observed in the proportion of alcoholic liver disease or drug-induced hepatitis in both study periods. The prevalence of viral hepatitis decreased in both genders, with hepatitis C decreasing from 32.4 to 9.7% for males and 35.4 to 10.8% for females, and OR=0.2; 95%CI 0.1-0.3 for both males and females. Similarly, the prevalence of hepatitis B decreased from 19.1 to 8.1% and OR=0.3; 95%CI 0.2-0.5 for males and 8.2 to 3.7% and OR=0.4; 95%CI 0.1-0.9 for females. The prevalence of autoimmune liver diseases increased only in males, from 2.1 to 5.9% and OR=2.9; 95%CI 1.2-6.6.
CONCLUSIONS: Over the past 4 years, there has been a shift in hospital admission profile at a Brazilian Hepatology Unit, with a decrease in viral hepatitis and an increase in autoimmune diseases and nonalcoholic fatty liver disease. Males were more affected at younger ages than females. Furthermore, ascites was the most prevalent cause of complications in both periods analyzed.
摘要：
目的：该研究的目的是比较2014-2017年至2019-2022年巴西肝病科住院患者的流行病学和临床资料。
方法：对上述时期的医院数据库进行回顾性分析。这项研究包括18岁以上因病毒性肝炎等疾病并发症而住院的患者，酒精性疾病,非酒精性脂肪性肝病,以及自身免疫性肝脏和药物性肝炎。
结果：在两个研究期间，中年男性占主导地位，比女性年轻。在第一阶段（2014-2017年），丙型肝炎（33.5％）是最普遍的入院原因，其次是酒精性肝病（31.7%）。在第二阶段（2019-2022年），非酒精性脂肪性肝病(38%)和酒精性肝病(27.6%)是最常见的入院原因.在两个研究期间，酒精性肝病或药物诱发性肝炎的比例均未观察到变化。病毒性肝炎的患病率在两种性别中都有所下降，男性丙型肝炎从32.4％下降到9.7％，女性从35.4％下降到10.8％，OR=0.2；男性和女性为95CI0.1-0.3。同样，乙型肝炎的患病率从19.1降至8.1％，OR=0.3；男性95CI为0.2-0.5，男性为8.2-3.7％，OR=0.4；女性为95CI0.1-0.9。自身免疫性肝病的患病率仅在男性中增加，从2.1到5.9%，OR=2.9；95CI1.2-6.6。
结论：在过去的4年里，巴西肝病科的入院情况发生了变化，病毒性肝炎减少，自身免疫性疾病和非酒精性脂肪性肝病增加。男性在年轻时受到的影响大于女性。此外，在分析的两个时期中，腹水是最常见的并发症原因。
方法：对上述时期的医院数据库进行回顾性分析。这项研究包括18岁以上因病毒性肝炎等疾病并发症而住院的患者，酒精性疾病,非酒精性脂肪性肝病,以及自身免疫性肝脏和药物性肝炎。
结果：在两个研究期间，中年男性占主导地位，比女性年轻。在第一阶段（2014-2017年），丙型肝炎（33.5％）是最普遍的入院原因，其次是酒精性肝病（31.7%）。在第二阶段（2019-2022年），非酒精性脂肪性肝病(38%)和酒精性肝病(27.6%)是最常见的入院原因.在两个研究期间，酒精性肝病或药物诱发性肝炎的比例均未观察到变化。病毒性肝炎的患病率在两种性别中都有所下降，男性丙型肝炎从32.4％下降到9.7％，女性从35.4％下降到10.8％，OR=0.2；男性和女性为95CI0.1-0.3。同样，乙型肝炎的患病率从19.1降至8.1％，OR=0.3；男性95CI为0.2-0.5，男性为8.2-3.7％，OR=0.4；女性为95CI0.1-0.9。自身免疫性肝病的患病率仅在男性中增加，从2.1到5.9%，OR=2.9；95CI1.2-6.6。
结论：在过去的4年里，巴西肝病科的入院情况发生了变化，病毒性肝炎减少，自身免疫性疾病和非酒精性脂肪性肝病增加。男性在年轻时受到的影响大于女性。此外，在分析的两个时期中，腹水是最常见的并发症原因。
