PDF(Pubmed)
Abstract：
Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system with the worst prognosis. Even after radical surgery, the majority of patients with GBC have difficulty achieving a clinical cure. The risk of tumor recurrence remains more than 65%, and the overall 5-year survival rate is less than 5%. The gut microbiota refers to a variety of microorganisms living in the human intestine, including bacteria, viruses and fungi, which profoundly affect the host state of general health, disease and even cancer. Over the past few decades, substantial evidence has supported that gut microbiota plays a critical role in promoting the progression of GBC. In this review, we summarize the functions, molecular mechanisms and recent advances of the intestinal microbiota in GBC. We focus on the driving role of bacteria in pivotal pathways, such as virulence factors, metabolites derived from intestinal bacteria, chronic inflammatory responses and ecological niche remodeling. Additionally, we emphasize the high level of correlation between viruses and fungi, especially EBV and Candida spp., with GBC. In general, this review not only provides a solid theoretical basis for the close relationship between gut microbiota and GBC but also highlights more potential research directions for further research in the future.
摘要：
胆囊癌（GBC）是胆道系统最常见的恶性肿瘤，预后最差。即使在根治性手术后，大多数GBC患者很难达到临床治愈.肿瘤复发的风险仍然超过65%。5年生存率低于5%。肠道微生物群是指生活在人体肠道中的各种微生物，包括细菌,病毒和真菌，深刻影响宿主的总体健康状况，疾病，甚至癌症。在过去的几十年里，大量证据支持肠道菌群在促进GBC的进展中起关键作用。在这次审查中,我们总结了功能，GBC中肠道菌群的分子机制和最新进展。我们专注于细菌在关键途径中的驱动作用，如毒力因子，来自肠道细菌的代谢物，慢性炎症反应和生态位重塑。此外,我们强调病毒和真菌之间的高度相关性，尤其是EBV和念珠菌。,GBC。总的来说,本综述不仅为肠道菌群与GBC的密切关系提供了坚实的理论基础，而且为今后的进一步研究指明了更多潜在的研究方向。
