Abstract：
The coronavirus disease 2019 pandemic highlighted the need for more rapid and routine application of modeling approaches such as quantitative microbial risk assessment (QMRA) for protecting public health. QMRA is a transdisciplinary science dedicated to understanding, predicting, and mitigating infectious disease risks. To better equip QMRA researchers to inform policy and public health management, an Advances in Research for QMRA workshop was held to synthesize a path forward for QMRA research. We summarize insights from 41 QMRA researchers and experts to clarify the role of QMRA in risk analysis by (1) identifying key research needs, (2) highlighting emerging applications of QMRA; and (3) describing data needs and key scientific efforts to improve the science of QMRA. Key identified research priorities included using molecular tools in QMRA, advancing dose-response methodology, addressing needed exposure assessments, harmonizing environmental monitoring for QMRA, unifying a divide between disease transmission and QMRA models, calibrating and/or validating QMRA models, modeling co-exposures and mixtures, and standardizing practices for incorporating variability and uncertainty throughout the source-to-outcome continuum. Cross-cutting needs identified were to: develop a community of research and practice, integrate QMRA with other scientific approaches, increase QMRA translation and impacts, build communication strategies, and encourage sustainable funding mechanisms. Ultimately, a vision for advancing the science of QMRA is outlined for informing national to global health assessments, controls, and policies.
摘要：
2019年冠状病毒病的大流行强调了需要更快速和常规地应用建模方法，如定量微生物风险评估(QMRA)来保护公众健康。QMRA是一门跨学科的科学，致力于理解，预测，减轻传染病风险。为了更好地让QMRA研究人员为政策和公共卫生管理提供信息，举行了QMRA研究进展研讨会，以综合QMRA研究的前进道路。我们总结了41名QMRA研究人员和专家的见解，以通过（1）确定关键研究需求来阐明QMRA在风险分析中的作用，（2）强调QMRA的新兴应用；（3）描述数据需求和改善QMRA科学的关键科学努力。确定的关键研究重点包括在QMRA中使用分子工具，推进剂量反应方法，解决所需的暴露评估，协调QMRA的环境监测，统一了疾病传播和QMRA模型之间的鸿沟，校准和/或验证QMRA模型，建模共同曝光和混合，以及在整个来源到结果连续体中纳入变异性和不确定性的标准化做法。确定的交叉需求是:发展一个研究和实践社区，将QMRA与其他科学方法相结合，增加QMRA的翻译和影响，建立沟通策略，鼓励可持续的筹资机制。最终,概述了推进QMRA科学的愿景，以告知国家到全球的健康评估，controls,和政策。
