Abstract：
Mycotoxins in animal feed pose health risks and economic losses, but using various adsorbent types could potentially protect animals from mycotoxicosis. The study aimed to assess the effect of OTA on the health of broiler chickens and to envisage the ameliorative potential of clay adsorbents. The objectives of this in vivo study were to investigate the effects of OTA on productivity, biochemical parameters, fecal residues, and the preventive effects of indigenous and commercial clay of Balochistan as adsorbents to alleviate the adverse effects of exposure. Male broiler chickens (n = 160) were treated with 400 μg/kg OTA and 0.5 g/kg clay adsorbent for 42 days, with feed and water available in an ad libitum manner. The amount of OTA in diet and fecal residues was assessed through HPLC. The administration of OTA in the diet, resulted in a significant (p < 0.05) decrease in the average daily gain (ADG) and average daily feed intake (ADFI) while increasing the feed conversion ratio (FCR) as compared to the control group. Furthermore, no significant (p > 0.05) differences were found between the weight gain of broiler chickens fed without OTA (positive control) and that of chickens fed adsorbent. The group given a diet containing OTA without adsorbents as compared to the control and adsorbent-supplemented group has shown a significant (p < 0.05) increase in the relative weight of the liver, kidney, gizzard, and proventriculus while decreasing the relative weight of the spleen and bursa of Fabricius. Alterations in the levels of serum total protein (TP), cholesterol (CHL), serum urea (SU), enzymatic activity (aspartate aminotransferase (AST) and alanine transaminase (ALT)), and creatinine were observed in the OTA-intoxicated and adsorbent-supplemented groups as compared to the control group. Adsorbent supplementation resulted in a significantly (p < 0.05) higher OTA content in the faeces. It can be concluded from the results of this study, that OTA intoxication negatively affects the health of broiler chickens, and the clay of Balochistan has shown effective adsorption potential against OTA.
摘要：
动物饲料中的霉菌毒素会带来健康风险和经济损失，但是使用各种吸附剂类型可以潜在地保护动物免受霉菌毒性。该研究旨在评估OTA对肉鸡健康的影响，并设想粘土吸附剂的改善潜力。这项体内研究的目的是研究OTA对生产力的影响，生化参数，粪便残留物，以及Bal路支省土著和商业粘土作为吸附剂的预防作用，以减轻暴露的不利影响。雄性肉鸡（n=160）用400μg/kgOTA和0.5g/kg粘土吸附剂处理42天，以随意的方式提供饲料和水。通过HPLC评估饮食和粪便残留物中OTA的量。OTA在饮食中的管理，与对照组相比，导致平均日增重（ADG）和平均日采食量（ADFI）显着降低（p<0.05），同时增加了饲料转化率（FCR）。此外，未饲喂OTA（阳性对照）的肉鸡的增重与饲喂吸附剂的增重之间没有显着差异（p>0.05）。与对照组和补充吸附剂的组相比，给予不含吸附剂的OTA饮食的组显示肝脏相对重量的显着增加（p<0.05）。肾,Gizzard,和proventriculus，同时降低Fabricius的脾脏和法氏囊的相对重量。血清总蛋白（TP）水平的变化，胆固醇（CHL），血清尿素（SU），酶活性（天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）），与对照组相比，在OTA中毒和补充吸附剂的组中观察到肌酐。吸附剂补充导致粪便中显著(p<0.05)更高的OTA含量。从这项研究的结果可以得出结论，OTA中毒会对肉鸡的健康产生负面影响，俾路支省的粘土对OTA显示出有效的吸附潜力。
