Abstract：
BACKGROUND: The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide.
METHODS: A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.
RESULTS: The median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.
CONCLUSIONS: The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.
METHODS: A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.
RESULTS: The median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.
CONCLUSIONS: The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.
摘要：
背景：目前的研究提出了一个全球合作小组的努力，以审查全世界颅底恶性肿瘤的管理和结果。
方法：共有28个机构提供了3061名患者的数据。分析评估了临床变量，生存结果，以及与结果相关的多变量因素。
结果：中位年龄为56岁（IQR44-67）。55%(n=1680)的病例采用开放手术入路,36％（n=1087）进行了内镜切除术，合并方法为9.6%(n=294)。中位随访时间为7.1年，5年OSDSS和RFS为65%，71.7%和53%，分别。在多变量分析中，年龄较大,合并症,组织学,硬脑膜/颅内受累，正利润率，高级阶段,和原发灶是OS的独立预后因素，DSS,和RFS。辅助RT是一个保护性预后因素。
结论：与以前的报告相比，本研究中不同学科的进展可能有助于改善OS和DSS。
方法：共有28个机构提供了3061名患者的数据。分析评估了临床变量，生存结果，以及与结果相关的多变量因素。
结果：中位年龄为56岁（IQR44-67）。55%(n=1680)的病例采用开放手术入路,36％（n=1087）进行了内镜切除术，合并方法为9.6%(n=294)。中位随访时间为7.1年，5年OSDSS和RFS为65%，71.7%和53%，分别。在多变量分析中，年龄较大,合并症,组织学,硬脑膜/颅内受累，正利润率，高级阶段,和原发灶是OS的独立预后因素，DSS,和RFS。辅助RT是一个保护性预后因素。
结论：与以前的报告相比，本研究中不同学科的进展可能有助于改善OS和DSS。
