%0 Journal Article
%T Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015).
%A Shah JP
%A Levyn H
%A Valero C
%A Adilbay D
%A Eagan A
%A Zheng J
%A Gonen M
%A Cohen M
%A Patel S
%A Ganly I
%A Pai P
%A Castelnuovo P
%A Gao FJ
%A Piazza C
%A Nicolai P
%A Panizza B
%A Bowman J
%A Barnett C
%A Kowalski LP
%A Toledo R
%A Fliss DM
%A DeAlmeida J
%A Witterick I
%A Herman P
%A Fontanella W
%A Aniceto GS
%A Hosal S
%A Ozer S
%A Iyer S
%A Harvey R
%A Leemans CR
%A Hendrickx JJ
%A Figari M
%A Boccalatte L
%A Nibu KI
%A Clarke P
%A Rennie C
%A Ming ZY
%A Cernea C
%A Goncalves S
%A Schlosser R
%A Dias F
%A Sargi Z
%A Ahmed S
%A Golusinski W
%A Kim SH
%A Su SY
%A Raza SM
%A DeMonte F
%A Hanna E
%J Head Neck
%V 0
%N 0
%D 2024 May 21
%M 38770972
%F 3.821
%R 10.1002/hed.27746
%X <B>BACKGROUND: </B>The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide.<BR><B>METHODS: </B>A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.<BR><B>RESULTS: </B>The median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.<BR><B>CONCLUSIONS: </B>The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.