{Reference Type}: Journal Article
{Title}: Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015).
{Author}: Shah JP;Levyn H;Valero C;Adilbay D;Eagan A;Zheng J;Gonen M;Cohen M;Patel S;Ganly I;Pai P;Castelnuovo P;Gao FJ;Piazza C;Nicolai P;Panizza B;Bowman J;Barnett C;Kowalski LP;Toledo R;Fliss DM;DeAlmeida J;Witterick I;Herman P;Fontanella W;Aniceto GS;Hosal S;Ozer S;Iyer S;Harvey R;Leemans CR;Hendrickx JJ;Figari M;Boccalatte L;Nibu KI;Clarke P;Rennie C;Ming ZY;Cernea C;Goncalves S;Schlosser R;Dias F;Sargi Z;Ahmed S;Golusinski W;Kim SH;Su SY;Raza SM;DeMonte F;Hanna E;
{Journal}: Head Neck
{Volume}: 0
{Issue}: 0
{Year}: 2024 May 21
{Factor}: 3.821
{DOI}: 10.1002/hed.27746
{Abstract}: <B>BACKGROUND: </B>The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide.<BR><B>METHODS: </B>A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.<BR><B>RESULTS: </B>The median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.<BR><B>CONCLUSIONS: </B>The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.