PDF(Pubmed)
Abstract：
UNASSIGNED: Pediatric obesity is associated with impaired cognitive function; however, the mechanisms underlying this association demand assessment. Sleep may be a relevant moderator, as poor sleep predicts both increased adiposity and impaired cognitive function.
UNASSIGNED: To determine the effects of adiposity and sleep on adolescent cognitive function.
UNASSIGNED: This single-blind randomized crossover trial was conducted from September 2020 to October 2022. Parents or caregivers provided demographic information for adolescent participants. Body mass index percentile and bioelectrical impedance analysis assessed adiposity. Adolescents completed 2 actigraphy-confirmed sleep conditions, adequate and restricted, followed by in-person cognitive assessment. No additional follow-up was provided. Data collection for this population-based study took place in a behavioral medicine clinic in Birmingham, Alabama. A total of 323 participants were assessed for eligibility (ages 14-19 years and healthy). Of the 244 eligible adolescents, 157 declined participation. Eighty-seven were randomized and 26 dropped out postenrollment. The final sample included 61 adolescents, 31 with healthy weight and 30 with overweight or obesity. Data were analyzed from April to October 2023.
UNASSIGNED: Following a 2-day washout period of adequate sleep, adolescents completed 2 sleep conditions: adequate (mean [SD] duration, 8 hours, 54 minutes [58.0 minutes]) and restricted (mean [SD] duration, 4 hours, 12 minutes [50.7 minutes]).
UNASSIGNED: The National Institutes of Health Cognitive Toolbox assessed global and fluid cognition, cognitive flexibility, working and episodic memory, attention, and processing speed. The Stroop Task assessed inhibition.
UNASSIGNED: The final sample included 61 adolescents (mean [SD] age, 16.3 [1.6] years; 35 [57.4%] female). Restricted sleep predicted poorer global cognition scores (restricted mean [SD], 98.0 [2.8]; adequate mean [SD], 103.2 [2.9]), fluid cognition scores (restricted mean [SD], 94.5 [3.2]; adequate mean [SD], 102.0 [3.6]), and cognitive flexibility scores (restricted mean [SD], 84.8 [3.0]; adequate mean [SD], 92.8 [3.0]) for adolescents with overweight or obesity. No differences emerged for adolescents with healthy weight. Adolescents with overweight or obesity also had poorer attention scores (mean [SD], 80.0 [2.3]) compared to adolescents with healthy weight (mean [SD], 88.4 [SD, 2.3]) following restricted sleep. No differences emerged following adequate sleep. Findings were similar for total body fat percentage (TBF%); however, for adolescents with TBF% above 42, restricted sleep also predicted poorer processing speed, and the association between sleep and attention did not vary based on TBF%.
UNASSIGNED: Adolescents with overweight or obesity may be more vulnerable to negative cognitive effects following sleep restriction. Improved sleep hygiene and duration in this group may positively impact their cognitive health.
UNASSIGNED: ClinicalTrials.gov Identifier: NCT04346433.
UNASSIGNED: To determine the effects of adiposity and sleep on adolescent cognitive function.
UNASSIGNED: This single-blind randomized crossover trial was conducted from September 2020 to October 2022. Parents or caregivers provided demographic information for adolescent participants. Body mass index percentile and bioelectrical impedance analysis assessed adiposity. Adolescents completed 2 actigraphy-confirmed sleep conditions, adequate and restricted, followed by in-person cognitive assessment. No additional follow-up was provided. Data collection for this population-based study took place in a behavioral medicine clinic in Birmingham, Alabama. A total of 323 participants were assessed for eligibility (ages 14-19 years and healthy). Of the 244 eligible adolescents, 157 declined participation. Eighty-seven were randomized and 26 dropped out postenrollment. The final sample included 61 adolescents, 31 with healthy weight and 30 with overweight or obesity. Data were analyzed from April to October 2023.
UNASSIGNED: Following a 2-day washout period of adequate sleep, adolescents completed 2 sleep conditions: adequate (mean [SD] duration, 8 hours, 54 minutes [58.0 minutes]) and restricted (mean [SD] duration, 4 hours, 12 minutes [50.7 minutes]).
UNASSIGNED: The National Institutes of Health Cognitive Toolbox assessed global and fluid cognition, cognitive flexibility, working and episodic memory, attention, and processing speed. The Stroop Task assessed inhibition.
UNASSIGNED: The final sample included 61 adolescents (mean [SD] age, 16.3 [1.6] years; 35 [57.4%] female). Restricted sleep predicted poorer global cognition scores (restricted mean [SD], 98.0 [2.8]; adequate mean [SD], 103.2 [2.9]), fluid cognition scores (restricted mean [SD], 94.5 [3.2]; adequate mean [SD], 102.0 [3.6]), and cognitive flexibility scores (restricted mean [SD], 84.8 [3.0]; adequate mean [SD], 92.8 [3.0]) for adolescents with overweight or obesity. No differences emerged for adolescents with healthy weight. Adolescents with overweight or obesity also had poorer attention scores (mean [SD], 80.0 [2.3]) compared to adolescents with healthy weight (mean [SD], 88.4 [SD, 2.3]) following restricted sleep. No differences emerged following adequate sleep. Findings were similar for total body fat percentage (TBF%); however, for adolescents with TBF% above 42, restricted sleep also predicted poorer processing speed, and the association between sleep and attention did not vary based on TBF%.
UNASSIGNED: Adolescents with overweight or obesity may be more vulnerable to negative cognitive effects following sleep restriction. Improved sleep hygiene and duration in this group may positively impact their cognitive health.
UNASSIGNED: ClinicalTrials.gov Identifier: NCT04346433.
摘要：
■小儿肥胖与认知功能受损有关；然而，这种协会需求评估的基础机制。睡眠可能是相关的主持人，睡眠不佳预示着肥胖增加和认知功能受损。
■确定肥胖和睡眠对青少年认知功能的影响。
■这项单盲随机交叉试验于2020年9月至2022年10月进行。父母或照顾者为青少年参与者提供人口统计信息。体重指数百分位数和生物电阻抗分析评估肥胖。青少年完成了2种活动记录确认的睡眠条件，充足和受限，其次是面对面的认知评估。没有提供额外的后续行动。这项基于人群的研究的数据收集是在伯明翰的行为医学诊所进行的，阿拉巴马.总共对323名参与者进行了资格评估（年龄14-19岁，健康）。在244名符合条件的青少年中，157人拒绝参与。87人被随机分配，26人在入学后退出。最终样本包括61名青少年，31人体重健康，30人超重或肥胖。数据从2023年4月到10月进行了分析。
■经过2天的充足睡眠后，青少年完成了2种睡眠条件：充足(平均[SD]持续时间，8小时,54分钟[58.0分钟])和受限(平均[SD]持续时间，4小时,12分钟[50.7分钟]）。
■美国国立卫生研究院认知工具箱评估了全球和流体认知，认知灵活性，工作和情景记忆，注意,和处理速度。Stroop任务评估了抑制。
■最终样本包括61名青少年(平均[SD]年龄，16.3[1.6]岁；35[57.4%]女性)。受限睡眠预测全球认知得分较差(受限平均值[SD]，98.0[2.8]；足够的平均值[SD]，103.2[2.9])，流体认知评分(限制平均值[SD]，94.5[3.2]；足够的平均值[SD]，102.0[3.6])，和认知灵活性得分(受限平均值[SD]，84.8[3.0]；足够的平均值[SD]，92.8[3.0]）适用于超重或肥胖的青少年。体重健康的青少年没有差异。超重或肥胖的青少年注意力得分也较差(平均值[SD]，80.0[2.3])与健康体重的青少年(平均值[SD]，88.4[SD,2.3])限制睡眠后。充足的睡眠后没有差异。总体脂肪百分比(TBF%)的结果相似；然而，对于TBF％高于42的青少年，有限的睡眠也预示着处理速度较差，睡眠和注意力之间的关联根据TBF%没有变化。
超重或肥胖的青少年在睡眠受限后可能更容易受到负面认知影响。改善该组的睡眠卫生和持续时间可能会对他们的认知健康产生积极影响。
■ClinicalTrials.gov标识符：NCT04346433。
■确定肥胖和睡眠对青少年认知功能的影响。
■这项单盲随机交叉试验于2020年9月至2022年10月进行。父母或照顾者为青少年参与者提供人口统计信息。体重指数百分位数和生物电阻抗分析评估肥胖。青少年完成了2种活动记录确认的睡眠条件，充足和受限，其次是面对面的认知评估。没有提供额外的后续行动。这项基于人群的研究的数据收集是在伯明翰的行为医学诊所进行的，阿拉巴马.总共对323名参与者进行了资格评估（年龄14-19岁，健康）。在244名符合条件的青少年中，157人拒绝参与。87人被随机分配，26人在入学后退出。最终样本包括61名青少年，31人体重健康，30人超重或肥胖。数据从2023年4月到10月进行了分析。
■经过2天的充足睡眠后，青少年完成了2种睡眠条件：充足(平均[SD]持续时间，8小时,54分钟[58.0分钟])和受限(平均[SD]持续时间，4小时,12分钟[50.7分钟]）。
■美国国立卫生研究院认知工具箱评估了全球和流体认知，认知灵活性，工作和情景记忆，注意,和处理速度。Stroop任务评估了抑制。
■最终样本包括61名青少年(平均[SD]年龄，16.3[1.6]岁；35[57.4%]女性)。受限睡眠预测全球认知得分较差(受限平均值[SD]，98.0[2.8]；足够的平均值[SD]，103.2[2.9])，流体认知评分(限制平均值[SD]，94.5[3.2]；足够的平均值[SD]，102.0[3.6])，和认知灵活性得分(受限平均值[SD]，84.8[3.0]；足够的平均值[SD]，92.8[3.0]）适用于超重或肥胖的青少年。体重健康的青少年没有差异。超重或肥胖的青少年注意力得分也较差(平均值[SD]，80.0[2.3])与健康体重的青少年(平均值[SD]，88.4[SD,2.3])限制睡眠后。充足的睡眠后没有差异。总体脂肪百分比(TBF%)的结果相似；然而，对于TBF％高于42的青少年，有限的睡眠也预示着处理速度较差，睡眠和注意力之间的关联根据TBF%没有变化。
超重或肥胖的青少年在睡眠受限后可能更容易受到负面认知影响。改善该组的睡眠卫生和持续时间可能会对他们的认知健康产生积极影响。
■ClinicalTrials.gov标识符：NCT04346433。
