Abstract：
UNASSIGNED: Hantavirus and dengue virus infections lead to diseases causing economic and public health concerns. Acute hantavirus infections can lead to similar clinical haemorrhagic signs as other endemic diseases including dengue and leptospirosis.
UNASSIGNED: Using a retrospective case analysis of pregnant dengue and hantavirus disease patients with clinical reports and compatible clinical laboratory information during pregnancy, we report the first evidence of dengue and hantavirus infections and a case of dual dengue and hantavirus infection among pregnant women in the Caribbean. Laboratory testing by enzyme-linked immunosorbent assay (ELISA) and non-structural protein 1 (NS1) for DENV and for hantavirus infection pseudotype focus reduction neutralisation tests (pFRNT), ELISA and immunochromatographic (ICG) strips.
UNASSIGNED: Four pregnant cases with acute DENV infections were identified; however, only one out of the four cases (25%) had a detailed medical record to permit abstraction of clinical data. Six hantavirus infected pregnant cases were identified with gestation periods ranged from 36 to 39 weeks; none of the reported patients exhibited previous pregnancy complications prior to hospitalisation and infection. Acute liver damage was observed in three of the six cases (AST readings) who were subsequently diagnosed with hepatitis in pregnancy and variable clinical outcomes were observed with term and pre-term deliveries.
UNASSIGNED: Whilst hantavirus infection in pregnancy is rare, consideration should be given to differential diagnosis with fever, kidney involvement, liver involvement, haemorrhagic symptoms and thrombocytopenia in endemic areas with clinically similar diseases such as dengue and leptospirosis.HighlightsFirst recorded case of hantavirus and dengue co-infection in a pregnant woman.First detailed report of clinical hantavirus infection in pregnant women in the Caribbean.First published report of clinical dengue infection in pregnant woman in the Caribbean.Possible complications of pregnancy following hantavirus infection.Pre-term birth and low birth weights.Clinical course of hantavirus infection in a Caribbean population.
UNASSIGNED: Using a retrospective case analysis of pregnant dengue and hantavirus disease patients with clinical reports and compatible clinical laboratory information during pregnancy, we report the first evidence of dengue and hantavirus infections and a case of dual dengue and hantavirus infection among pregnant women in the Caribbean. Laboratory testing by enzyme-linked immunosorbent assay (ELISA) and non-structural protein 1 (NS1) for DENV and for hantavirus infection pseudotype focus reduction neutralisation tests (pFRNT), ELISA and immunochromatographic (ICG) strips.
UNASSIGNED: Four pregnant cases with acute DENV infections were identified; however, only one out of the four cases (25%) had a detailed medical record to permit abstraction of clinical data. Six hantavirus infected pregnant cases were identified with gestation periods ranged from 36 to 39 weeks; none of the reported patients exhibited previous pregnancy complications prior to hospitalisation and infection. Acute liver damage was observed in three of the six cases (AST readings) who were subsequently diagnosed with hepatitis in pregnancy and variable clinical outcomes were observed with term and pre-term deliveries.
UNASSIGNED: Whilst hantavirus infection in pregnancy is rare, consideration should be given to differential diagnosis with fever, kidney involvement, liver involvement, haemorrhagic symptoms and thrombocytopenia in endemic areas with clinically similar diseases such as dengue and leptospirosis.HighlightsFirst recorded case of hantavirus and dengue co-infection in a pregnant woman.First detailed report of clinical hantavirus infection in pregnant women in the Caribbean.First published report of clinical dengue infection in pregnant woman in the Caribbean.Possible complications of pregnancy following hantavirus infection.Pre-term birth and low birth weights.Clinical course of hantavirus infection in a Caribbean population.
摘要：
■汉坦病毒和登革热病毒感染导致引起经济和公共卫生问题的疾病。急性汉坦病毒感染可导致与其他地方病（包括登革热和钩端螺旋体病）相似的临床出血体征。
■使用妊娠登革热和汉坦病毒病患者的回顾性病例分析，并在怀孕期间提供临床报告和兼容的临床实验室信息，我们报告了加勒比地区孕妇中登革热和汉坦病毒感染的第一个证据以及一例登革热和汉坦病毒双重感染病例.通过酶联免疫吸附测定（ELISA）和非结构蛋白1（NS1）进行DENV和汉坦病毒感染假型病灶减少中和试验（pFRNT）的实验室检测，ELISA和免疫层析(ICG)试纸条。
■确定了4例急性DENV感染的孕妇；然而，4例病例中只有1例(25%)有详细的病历,可以提取临床数据.确定了6例汉坦病毒感染的孕妇，其妊娠期为36至39周；报告的患者在住院和感染之前均未出现先前的妊娠并发症。在随后诊断为妊娠肝炎的6例（AST读数）中的3例中观察到急性肝损伤，并观察到足月和早产的不同临床结果。
■虽然在怀孕期间汉坦病毒感染很少见，应考虑与发热的鉴别诊断，肾脏受累，肝脏受累,登革热和钩端螺旋体病等临床类似疾病流行地区的出血症状和血小板减少症。亮点首例记录的孕妇汉坦病毒和登革热共感染病例。加勒比地区孕妇临床汉坦病毒感染的第一份详细报告。加勒比海地区孕妇临床登革热感染的首次发表报告。汉坦病毒感染后可能的妊娠并发症。早产和低出生体重。加勒比海人群汉坦病毒感染的临床过程。
■使用妊娠登革热和汉坦病毒病患者的回顾性病例分析，并在怀孕期间提供临床报告和兼容的临床实验室信息，我们报告了加勒比地区孕妇中登革热和汉坦病毒感染的第一个证据以及一例登革热和汉坦病毒双重感染病例.通过酶联免疫吸附测定（ELISA）和非结构蛋白1（NS1）进行DENV和汉坦病毒感染假型病灶减少中和试验（pFRNT）的实验室检测，ELISA和免疫层析(ICG)试纸条。
■确定了4例急性DENV感染的孕妇；然而，4例病例中只有1例(25%)有详细的病历,可以提取临床数据.确定了6例汉坦病毒感染的孕妇，其妊娠期为36至39周；报告的患者在住院和感染之前均未出现先前的妊娠并发症。在随后诊断为妊娠肝炎的6例（AST读数）中的3例中观察到急性肝损伤，并观察到足月和早产的不同临床结果。
■虽然在怀孕期间汉坦病毒感染很少见，应考虑与发热的鉴别诊断，肾脏受累，肝脏受累,登革热和钩端螺旋体病等临床类似疾病流行地区的出血症状和血小板减少症。亮点首例记录的孕妇汉坦病毒和登革热共感染病例。加勒比地区孕妇临床汉坦病毒感染的第一份详细报告。加勒比海地区孕妇临床登革热感染的首次发表报告。汉坦病毒感染后可能的妊娠并发症。早产和低出生体重。加勒比海人群汉坦病毒感染的临床过程。
