PDF(Pubmed)
Abstract：
This study aimed to examine the effect of acute exogenous melatonin administration on salivary cortisol and alpha-amylase (sCort and sAA) as representatives of the HPA axis and the sympathetic nervous system, respectively. A single-dose prolonged-release melatonin (2 mg) or a placebo tablet was given to healthy volunteers (n = 64) at 20:00 h in a crossover design. The saliva was collected at six time points (20:00, 21:00, awakening, 30 min after awakening, 10:00, and 12:00 h) and was measured for sCort, sAA, and salivary melatonin (sMT) levels. Pulse rates and sleep parameters were also collected. Melatonin was effective in improving sleep onset latency by 7:04 min (p = .037) and increasing total sleep time by 24 min (p = .006). Participants with poor baseline sleep quality responded more strongly to melatonin than participants with normal baseline sleep quality as they reported more satisfaction in having adequate sleep (p = .017). Melatonin administration resulted in higher sCort levels at awakening time point (p = .023) and a tendency of lower sAA levels but these were not significant. Melatonin ingestion at 20:00 h resulted in a marked increase in sMT levels at 21:00 h and remained higher than baseline up to at least 10:00 h (p < .001). Melatonin increases sCort levels at certain time point with a tendency to lower sAA levels. These opposing effects of melatonin suggested a complex interplay between melatonin and these biomarkers. Also, the results confirmed the positive acute effect of a single-dose melatonin on sleep quality.
摘要：
这项研究旨在检查急性外源性褪黑激素给药对唾液皮质醇和α-淀粉酶（sCort和sAA）作为HPA轴和交感神经系统代表的影响，分别。在20:00h以交叉设计向健康志愿者（n=64）给予单剂量缓释褪黑激素（2mg）或安慰剂片剂。在六个时间点（20:00，21:00，觉醒，觉醒后30分钟，10:00和12:00h），并对sCort进行了测量，SAA,和唾液褪黑激素（sMT）水平。还收集脉搏率和睡眠参数。褪黑素可有效改善7:04分钟的睡眠发作潜伏期（p=.037），并将总睡眠时间增加24分钟（p=.006）。基线睡眠质量差的参与者对褪黑激素的反应比基线睡眠质量正常的参与者更强，因为他们报告对充足睡眠的满意度更高（p=0.017）。褪黑激素给药在觉醒时间点导致较高的sCort水平（p=.023）和较低的sAA水平的趋势，但这些并不明显。在20:00h时摄入褪黑素导致在21:00h时sMT水平显著增加,并保持高于基线直至至少10:00h(p<.001)。褪黑素在某些时间点增加sCort水平，并倾向于降低sAA水平。褪黑激素的这些相反作用表明褪黑激素与这些生物标志物之间存在复杂的相互作用。此外，结果证实了单剂量褪黑素对睡眠质量的积极急性作用。
