PDF(Pubmed)
Abstract：
OBJECTIVE: Individuals with chronic pain due to knee osteoarthritis (OA) are insufficiently physically active, and alterations of facilitatory and inhibitory nociceptive signaling are common in this population. Our objective was to examine the association of these alterations in nociceptive signaling with objective accelerometer-based measures of physical activity in a large observational cohort.
METHODS: We used data from the Multicenter Osteoarthritis Study. Measures of peripheral and central pain sensitivity included pressure pain threshold at the knee and mechanical temporal summation at the wrist, respectively. The presence of descending pain inhibition was assessed by conditioned pain modulation (CPM). Physical activity was quantitatively assessed over 7 days using a lower back-worn activity monitor. Summary metrics included steps/day, activity intensity, and sedentary time. Linear regression analyses were used to evaluate the association of pain sensitivity and the presence of descending pain inhibition with physical activity measures.
RESULTS: Data from 1873 participants was analyzed (55.9% female, age = 62.8 ± 10.0 years). People having greater peripheral and central sensitivity showed lower step counts. CPM was not significantly related to any of the physical activity measures, and none of the exposures were significantly related to sedentary time.
CONCLUSIONS: In this cohort, greater peripheral and central sensitivity were associated with reduced levels of objectively-assessed daily step counts. Further research may investigate ways to modify or treat heightened pain sensitivity as a means to increase physical activity in older adults with knee OA.
METHODS: We used data from the Multicenter Osteoarthritis Study. Measures of peripheral and central pain sensitivity included pressure pain threshold at the knee and mechanical temporal summation at the wrist, respectively. The presence of descending pain inhibition was assessed by conditioned pain modulation (CPM). Physical activity was quantitatively assessed over 7 days using a lower back-worn activity monitor. Summary metrics included steps/day, activity intensity, and sedentary time. Linear regression analyses were used to evaluate the association of pain sensitivity and the presence of descending pain inhibition with physical activity measures.
RESULTS: Data from 1873 participants was analyzed (55.9% female, age = 62.8 ± 10.0 years). People having greater peripheral and central sensitivity showed lower step counts. CPM was not significantly related to any of the physical activity measures, and none of the exposures were significantly related to sedentary time.
CONCLUSIONS: In this cohort, greater peripheral and central sensitivity were associated with reduced levels of objectively-assessed daily step counts. Further research may investigate ways to modify or treat heightened pain sensitivity as a means to increase physical activity in older adults with knee OA.
摘要：
目的：患有膝骨关节炎（OA）引起的慢性疼痛的人身体活动不足，在该人群中，促进和抑制伤害性信号的改变很常见。我们的目的是在大型观察队列中检查伤害性信号的这些改变与基于客观加速度计的身体活动测量之间的关联。
方法：我们使用了多中心骨关节炎研究（MOST）的数据。周围和中枢疼痛敏感性的测量包括膝关节的压力痛阈值（PPT）和手腕的机械时间总和（TS），分别。通过条件性疼痛调节(CPM)评估下降疼痛抑制的存在。使用较低的背部活动监测器对7天的身体活动进行定量评估。汇总指标包括步骤/天，活动强度,久坐的时间。线性回归分析用于评估疼痛敏感性和降低疼痛抑制的存在与身体活动测量的关联。
结果：分析了1,873名参与者的数据（55.9％为女性，年龄=62.8±10.0岁)。具有较高的外周和中枢敏感性的人显示较低的步数。CPM与任何身体活动措施都没有显着相关，没有一个暴露与久坐时间显着相关。
结论：在这个队列中，较高的外周和中枢敏感性与客观评估的每日步数水平降低相关.进一步的研究可能会研究改变或治疗疼痛敏感性升高的方法，作为增加膝关节OA老年人身体活动的一种手段。
方法：我们使用了多中心骨关节炎研究（MOST）的数据。周围和中枢疼痛敏感性的测量包括膝关节的压力痛阈值（PPT）和手腕的机械时间总和（TS），分别。通过条件性疼痛调节(CPM)评估下降疼痛抑制的存在。使用较低的背部活动监测器对7天的身体活动进行定量评估。汇总指标包括步骤/天，活动强度,久坐的时间。线性回归分析用于评估疼痛敏感性和降低疼痛抑制的存在与身体活动测量的关联。
结果：分析了1,873名参与者的数据（55.9％为女性，年龄=62.8±10.0岁)。具有较高的外周和中枢敏感性的人显示较低的步数。CPM与任何身体活动措施都没有显着相关，没有一个暴露与久坐时间显着相关。
结论：在这个队列中，较高的外周和中枢敏感性与客观评估的每日步数水平降低相关.进一步的研究可能会研究改变或治疗疼痛敏感性升高的方法，作为增加膝关节OA老年人身体活动的一种手段。
