目的:在心血管疾病(CVD)患者中,探讨加速度计测量的强度特异性体力活动(PA)与全因死亡率和因特异性死亡率的关系。
方法:在这项前瞻性队列研究中,8,024名预先存在心血管疾病的人(平均年龄:66.6岁,女性:34.1%)来自英国生物库的PA在2013-2015年的7天内使用腕部佩戴加速度计进行了测量。所有原因,癌症,从死亡登记处确定CVD死亡率。Cox回归模型和有限的三次样条用于评估关联。如果进行更多的PA,则使用人口归因分数(PAF)来估计可预防死亡的比例。
结果:在平均6.8年的随访中,记录了691例死亡(273例来自癌症,219例来自CVD)。PA持续时间和全因死亡风险之间存在反向非线性关联,无论PA强度。全因死亡率的危险比(HR)在1800分钟/周的光照强度PA(LPA),中等强度PA(MPA)每周320分钟,高强度PA(VPA)每周15分钟。PA的最高四分位数与全因死亡率的较低风险相关,HR为0.63(95%置信区间[CI]:0.51-0.79),LPA为0.42(0.33-0.54)和0.47(0.37-0.60),MPA,VPA,分别。癌症和CVD死亡率也观察到类似的关联。此外,最高的PAF是VPA,其次是MPA。
结论:我们发现PA的所有强度(LPA,MPA,VPA,和MVPA)和使用加速度计得出的数据的CVD患者的死亡风险,但与以前基于自我报告PA的研究相比,这种关联的幅度更大。
这项研究调查了心血管疾病(CVD)个体中加速度计衍生的强度特异性体力活动(PA)与全因和特定原因死亡率风险的关联。在所有水平的PA强度中观察到PA持续时间与全因死亡率之间的L形剂量反应关系。降低死亡率的风险表现出从0到1800分钟/周的光强度PA急剧下降,然后到达一个高原。值得注意的是,中等强度PA和剧烈强度PA的拐点在每周320和15分钟处发现,分别。人口归因分数分析表明,如果患有CVD的个体进行更剧烈的身体活动,则可以预防大量死亡。
OBJECTIVE: To investigate the association of
accelerometer-measured intensity-specific physical activity (PA) with all-cause and cause-specific mortality among individuals with cardiovascular disease (CVD).
METHODS: In this prospective cohort study, 8,024 individuals with pre-existing CVD (mean age: 66.6 years, female: 34.1%) from the UK Biobank had their PA measured using wrist-worn accelerometers over a 7-day period in 2013-2015. All-cause, cancer, and CVD mortality was ascertained from death registries. Cox regression modelling and restricted cubic splines were used to assess the associations. Population-attributable fractions (PAFs) were used to estimate the proportion of preventable deaths if more PA were undertaken.
RESULTS: During an average of 6.8 years of follow-up, 691 deaths (273 from cancer and 219 from CVD) were recorded. An inverse non-linear association was found between PA duration and all-cause mortality risk, irrespective of PA intensity. The hazard ratio (HR) of all-cause mortality plateaued at 1800 minutes/week for light-intensity PA (LPA), 320 minutes/week for moderate-intensity PA (MPA) and 15 minutes/week for vigorous-intensity PA (VPA). The highest quartile of PA associated lower risks for all-cause mortality, with HRs of 0.63 (95% confidence interval [CI]: 0.51-0.79), 0.42 (0.33-0.54) and 0.47 (0.37-0.60) for LPA, MPA, and VPA, respectively. Similar associations were observed for cancer and CVD mortality. Additionally, the highest PAF were noted for VPA, followed by MPA.
CONCLUSIONS: We found an inverse non-linear association between all intensities of PA (LPA, MPA, VPA, and MVPA) and mortality risk in CVD patients using
accelerometer-derived data, but with larger magnitude of the associations than that in previous studies based on self-reported PA.
This study investigated the associations of
accelerometer-derived intensity-specific physical activity (PA) with the risks of all-cause and cause-specific mortality among individuals with cardiovascular disease (CVD). L-shaped dose-response relationships between the duration of PA and all-cause mortality were observed across all levels of PA intensities. The risk reduction for mortality exhibited a sharp decline from 0 to 1800 minutes/week of light-intensity PA, followed by reaching a plateau. Notably, the inflection points for moderate-intensity PA and vigorous-intensity PA were found at 320 and 15 minutes per week, respectively. The population-attributable fraction analysis indicated that a significant number of deaths could potentially be prevented if individuals with CVD engaged in more vigorous physical activities.