Abstract：
This book chapter highlights a comprehensive exploration of the transformative innovations in the field of cancer immunotherapy. CAR (Chimeric Antigen Receptor) T-cell therapy represents a groundbreaking approach to treat cancer by reprogramming a patient immune cells to recognize and destroy cancer cells. This chapter underscores the critical role of synthetic biology in enhancing the safety and effectiveness of CAR T-cell therapies. It begins by emphasizing the growing importance of personalized medicine in cancer treatment, emphasizing the shift from one-size-fits-all approaches to patient-specific solutions. Synthetic biology, a multidisciplinary field, has been instrumental in customizing CAR T-cell therapies, allowing for fine-tuned precision and minimizing unwanted side effects. The chapter highlights recent advances in gene editing, synthetic gene circuits, and molecular engineering, showcasing how these technologies are optimizing CAR T-cell function. In summary, this book chapter sheds light on the remarkable progress made in the development of CAR T-cell therapies using synthetic biology, providing hope for cancer patients and hinting at a future where highly personalized and effective cancer treatments are the norm.
摘要：
本书本章重点介绍了对癌症免疫治疗领域变革性创新的全面探索。CAR(嵌合抗原受体)T细胞疗法代表了通过重新编程患者免疫细胞以识别和破坏癌细胞来治疗癌症的开创性方法。本章强调了合成生物学在增强CAR-T细胞疗法的安全性和有效性方面的关键作用。它首先强调个性化医疗在癌症治疗中日益重要，强调从一刀切的方法到针对患者的解决方案的转变。合成生物学,多学科领域，在定制CAR-T细胞疗法方面发挥了重要作用，允许微调精度和最大限度地减少不必要的副作用。本章重点介绍了基因编辑的最新进展，合成基因回路，和分子工程，展示这些技术如何优化CAR-T细胞功能。总之,本书的这一章阐明了使用合成生物学开发CAR-T细胞疗法的显着进展，为癌症患者提供希望，并暗示未来高度个性化和有效的癌症治疗是常态。
