{Reference Type}: Journal Article
{Title}: Recent advances in CAR T-cell engineering using synthetic biology: Paving the way for next-generation cancer treatment.
{Author}: Dey S;Devender M;Rani S;Pandey RK;
{Journal}: Adv Protein Chem Struct Biol
{Volume}: 140
{Issue}: 0
{Year}: 2024
{Factor}: 5.447
{DOI}: 10.1016/bs.apcsb.2024.02.003
{Abstract}: This book chapter highlights a comprehensive exploration of the transformative innovations in the field of cancer immunotherapy. CAR (Chimeric Antigen Receptor) T-cell therapy represents a groundbreaking approach to treat cancer by reprogramming a patient immune cells to recognize and destroy cancer cells. This chapter underscores the critical role of synthetic biology in enhancing the safety and effectiveness of CAR T-cell therapies. It begins by emphasizing the growing importance of personalized medicine in cancer treatment, emphasizing the shift from one-size-fits-all approaches to patient-specific solutions. Synthetic biology, a multidisciplinary field, has been instrumental in customizing CAR T-cell therapies, allowing for fine-tuned precision and minimizing unwanted side effects. The chapter highlights recent advances in gene editing, synthetic gene circuits, and molecular engineering, showcasing how these technologies are optimizing CAR T-cell function. In summary, this book chapter sheds light on the remarkable progress made in the development of CAR T-cell therapies using synthetic biology, providing hope for cancer patients and hinting at a future where highly personalized and effective cancer treatments are the norm.