Abstract：
OBJECTIVE: To assess the effects of timing of maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination status on placental transfer of antibodies to neonates.
METHODS: In this cross-sectional study, chemiluminescence was employed to measure SARS-CoV-2 IgG antibody titers in paired maternal-infant samples from women infected during pregnancy who were vaccinated or unvaccinated. Generalized linear regression assessed factors affecting antibody transfer in infected pregnant women and neonatal titers.
RESULTS: The group with ≥90 days between infection and delivery showed a higher antibody transfer rate than the <90 days group (β= 0.33, 95%CI: 0.01-0.65). Neonatal IgG titers correlated significantly with maternal titers and with maternal infections more than 90 days before delivery. Among infected pregnant women, those who had received 2 or 3 doses of vaccine before pregnancy had higher neonatal antibody titers than those who were not vaccinated (β = 57.70, 95%CI: 31.33-84.07).
CONCLUSIONS: Neonates born to pregnant women who were vaccinated before infection showed higher antibody titers than neonates of pregnant women who were not vaccinated before infection. The transfer rate is higher in pregnant women with ≥90 days from infection to delivery than in those with <90 days. These findings highlight the importance of timely maternal vaccination to optimize maternal and infant immunity.
METHODS: In this cross-sectional study, chemiluminescence was employed to measure SARS-CoV-2 IgG antibody titers in paired maternal-infant samples from women infected during pregnancy who were vaccinated or unvaccinated. Generalized linear regression assessed factors affecting antibody transfer in infected pregnant women and neonatal titers.
RESULTS: The group with ≥90 days between infection and delivery showed a higher antibody transfer rate than the <90 days group (β= 0.33, 95%CI: 0.01-0.65). Neonatal IgG titers correlated significantly with maternal titers and with maternal infections more than 90 days before delivery. Among infected pregnant women, those who had received 2 or 3 doses of vaccine before pregnancy had higher neonatal antibody titers than those who were not vaccinated (β = 57.70, 95%CI: 31.33-84.07).
CONCLUSIONS: Neonates born to pregnant women who were vaccinated before infection showed higher antibody titers than neonates of pregnant women who were not vaccinated before infection. The transfer rate is higher in pregnant women with ≥90 days from infection to delivery than in those with <90 days. These findings highlight the importance of timely maternal vaccination to optimize maternal and infant immunity.
摘要：
目的：评估孕产妇严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染时机和疫苗接种状态对胎盘抗体向新生儿转移的影响。
方法：在这项横断面研究中，化学发光用于测量在怀孕期间感染或未接种疫苗的妇女的配对母婴样本中的SARS-CoV-2IgG抗体滴度。广义线性回归评估了感染孕妇和新生儿滴度中影响抗体转移的因素。
结果：感染和分娩之间≥90天的组显示出比<90天组更高的抗体转移率（β=0.33，95CI：0.01-0.65）。新生儿IgG滴度与产妇滴度和分娩前90天以上的产妇感染显着相关。在受感染的孕妇中，在怀孕前接种过2或3剂疫苗的新生儿抗体滴度高于未接种疫苗的新生儿(β=57.70,95CI:31.33~84.07).
结论：感染前接种疫苗的孕妇所生新生儿的抗体滴度高于感染前未接种疫苗的孕妇新生儿。从感染到分娩≥90天的孕妇的转移率高于<90天的孕妇。这些发现强调了及时接种母体疫苗以优化母婴免疫力的重要性。
方法：在这项横断面研究中，化学发光用于测量在怀孕期间感染或未接种疫苗的妇女的配对母婴样本中的SARS-CoV-2IgG抗体滴度。广义线性回归评估了感染孕妇和新生儿滴度中影响抗体转移的因素。
结果：感染和分娩之间≥90天的组显示出比<90天组更高的抗体转移率（β=0.33，95CI：0.01-0.65）。新生儿IgG滴度与产妇滴度和分娩前90天以上的产妇感染显着相关。在受感染的孕妇中，在怀孕前接种过2或3剂疫苗的新生儿抗体滴度高于未接种疫苗的新生儿(β=57.70,95CI:31.33~84.07).
结论：感染前接种疫苗的孕妇所生新生儿的抗体滴度高于感染前未接种疫苗的孕妇新生儿。从感染到分娩≥90天的孕妇的转移率高于<90天的孕妇。这些发现强调了及时接种母体疫苗以优化母婴免疫力的重要性。
