新型噻唑衍生物作为有效的 ALK5 抑制剂的设计和合成。
关键词: ALK5 Activin receptor-like kinases Kinase inhibitor TGF-β TGFβR1
Mesh : Thiazoles / chemistry pharmacology chemical synthesis Receptor, Transforming Growth Factor-beta Type I / antagonists & inhibitors metabolism Drug Design Humans Protein Kinase Inhibitors / pharmacology chemical synthesis chemistry Structure-Activity Relationship Protein Serine-Threonine Kinases / antagonists & inhibitors metabolism Receptors, Transforming Growth Factor beta / antagonists & inhibitors metabolism Molecular Structure Dose-Response Relationship, Drug
来 源: DOI:10.1016/j.bmcl.2024.129797