Abstract：
Physical and chemical signals in the central nervous system yield crucial information that is clinically relevant under both physiological and pathological conditions. The emerging field of bioelectronics focuses on the monitoring and manipulation of neurophysiological signals with high spatiotemporal resolution and minimal invasiveness. Significant advances have been realized through innovations in materials and structural design, which have markedly enhanced mechanical and electrical properties, biocompatibility, and overall device performance. The diagnostic and therapeutic potential of soft bioelectronics has been corroborated across a diverse array of pre-clinical settings. This review summarizes recent studies that underscore the developments and applications of soft bioelectronics in neurological disorders, including neuromonitoring, neuromodulation, tumor treatment, and biosensing. Limitations and outlooks of soft devices are also discussed in terms of power supply, wireless control, biocompatibility, and the integration of artificial intelligence. This review highlights the potential of soft bioelectronics as a future platform to promote deciphering brain functions and clinical outcomes of neurological diseases.
摘要：
中枢神经系统中的物理和化学信号产生在生理和病理条件下临床相关的关键信息。生物电子学的新兴领域专注于具有高时空分辨率和最小侵入性的神经生理信号的监测和操纵。通过材料和结构设计的创新，取得了重大进展，显著增强了机械和电气性能，生物相容性，和整体设备性能。软生物电子学的诊断和治疗潜力已经在各种临床前环境中得到证实。这篇综述总结了最近的研究，强调了软生物电子学在神经系统疾病中的发展和应用。包括神经监测,神经调节,肿瘤治疗,和生物传感。还从电源方面讨论了软设备的局限性和前景，无线控制,生物相容性，和人工智能的整合。这篇综述强调了软生物电子学作为促进破译神经系统疾病的脑功能和临床结果的未来平台的潜力。
