Abstract：
Evening chronotype is known to be associated with various chronic diseases and cardiovascular risk factors. Metabolic syndrome is a group of conditions that together raise the risk of coronary heart disease, diabetes, stroke, and other serious health problems. Only a few studies have been published on the association between chronotype and metabolic syndrome in unselected population data, with conflicting results. The aim of this study was to evaluate the association between chronotype and metabolic syndrome at population level by using unselected Northern Finland Birth cohort 1966 (NFBC1966) database. The study population consists of participants with NFBC66 (n = 5,113, 57% female) at the age of 46 yr old. Chronotype was determined with shortened Morningness-Eveningness Questionnaires and expressed as morning (44%), intermediate (44%), and evening types (12%). Metabolic syndrome was determined according to the definition of International Diabetes Federation. One-way ANOVA, Kruskal-Walli\'s test, and χ2 tests were used to compare the chronotype groups, followed by logistic regression analysis (adjusted with alcohol consumption, smoking, marital status, level of education, and leisure-time physical activity). In women, the prevalence of metabolic syndrome was statistically significantly higher in the evening type group: 23, 24, and 34% for morning, intermediate, and evening groups, respectively (P < 0.001). In logistic regression analysis, evening chronotype was associated with higher risk of having metabolic syndrome (OR 1.5; CI 95% 1.2 to 2.0). In this population-based birth cohort study, the evening chronotype was independently associated with higher prevalence of metabolic syndrome in women.NEW & NOTEWORTHY Only a few studies have been conducted on the association between chronotype and metabolic syndrome in unselected population data, with conflicting results. In this population-based cohort study of 5,113 participants, the evening chronotype associated with metabolic syndrome in women when there was no such association in men. The result supports a previous South Korean population study of 1,620 participants, in which the association was also found in women, but not in men.
摘要：
已知晚上型与各种慢性疾病和心血管危险因素有关。代谢综合征是一组共同增加冠心病风险的疾病，糖尿病,中风,以及其他严重的健康问题。在未选择的人群数据中，仅有少数研究发表了关于时间型和代谢综合征之间的关联。结果相互矛盾。这项研究的目的是通过使用未选择的北芬兰出生队列1966（NFBC1966）数据库，在人群水平上评估时间型与代谢综合征之间的关联。研究人群由46岁的NFBC66参与者（n=5113，57％为女性）组成。使用缩短的晨间-均匀性问卷确定时间型，并表示为晨间（44％），中级（44%）和晚间类型（12%）。根据国际糖尿病联合会的定义确定代谢综合征。单向方差分析,Kruskal-Walli检验和卡方检验用于比较时间型组，其次是逻辑回归分析(用饮酒校正，吸烟,婚姻状况,教育水平,和休闲时间体育活动)。在女性中，代谢综合征的患病率在晚间型组中有统计学意义:23%,24％和34％的早晨，中间和晚上组，分别（p<0,001）。在逻辑回归分析中，晚间时间型与代谢综合征的高风险相关(OR1.5;CI95%1.2~2.0).在这项基于人群的出生队列研究中，晚间时间型与女性代谢综合征患病率较高独立相关.
