全球范围内,乳腺癌仍然是女性癌症相关发病率和死亡率的主要原因.研究表明,睡眠模式显著影响肿瘤的发病和进展。在这项研究中,通过双样本孟德尔随机化(MR)方法检查了这种关联.为了分析七种睡眠模式,基因工具来自英国生物银行和23andMe,包括早上/晚上的人(时间型)n=177,604,早上的人(时间型)n=248,094,白天打瞌睡/嗜睡n=193,472,早上起床n=193,717,失眠n=193,987;睡眠时间n=192,810;白天午睡n=166,853。乳腺癌协会联合会(BCAC)提供了全基因组关联研究(GWAS)数据,包括133,384例乳腺癌病例和113,789例对照,与106,278例病例和91,477例对照的亚型特异性数据一起使用。我们发现,时间型包括早晨和晚上两种类型都会导致整体乳腺癌的风险。虽然白天打瞌睡和早晨的人(时间型)通常与乳腺癌的风险较低有关,在亚型特异性分析中,早晨的人(时间型)与腔B呈负相关,HER2阴性样,白天打瞌睡与管腔A样呈负相关,管腔B样,和HER2富集样。这项研究证实了时间型是乳腺癌的危险因素,与以前的观察结果一致。早晨的人(时间型)或白天打瞌睡与降低患乳腺癌风险之间的关联强调了睡眠模式在制定癌症预防策略中的重要性。
Globally, breast cancer continues to be the leading cause of cancer-related incidence and mortality among females. Research has shown that sleep patterns significantly influence tumor onset and progression. In this research, the association was examined through the application of a two-sample Mendelian randomization (MR) approach. For the analysis of seven sleep patterns, genetic tools were sourced from both the UK Biobank and 23andMe, including morning/evening person (
chronotype) n = 177,604, morning person (
chronotype) n = 248,094, daytime dozing/sleepiness n = 193,472, getting up in the morning n = 193,717, and sleeplessness n = 193,987; sleep duration n = 192,810; and nap during the day n = 166,853. The Breast Cancer Association Consortium (BCAC) supplied genome-wide association studies (GWAS) data, including 133,384 breast cancer cases and 113,789 controls, alongside subtype-specific data with 106,278 cases and 91,477 controls. We discovered that chronotype encompasses both morning and evening types contributes to the risk of overall breast cancer. While daytime dozing and morning person (chronotype) are linked to a lower risk of breast cancer in general, In subtype-specific analyses, morning person (
chronotype) was negatively associated with luminal B, HER2-negative-like, and daytime dozing was negatively correlated with luminal A-like, luminal B-like, and HER2-enriched-like. The study corroborates that
chronotype is a danger element for breast cancer, aligning with previous observational findings. The association between being a morning person (
chronotype) or having daytime dozing and a decreased risk of breast cancer underscores the significance of sleep patterns in formulating strategies for cancer prevention.