PDF(Pubmed)
Abstract：
UNASSIGNED: An increased level of interleukin-17A and interleukin-18 in the serum and intestinal mucosa of celiac disease patients reflecting the severity of villous atrophy and inflammation was documented. Thus, the objective of this study was to evaluate the concentrations of salivary-17A, interleukin-1 beta, and interleukin-18 in patients with celiac disease who are on a gluten-free diet, both with and without periodontitis, and to compare these levels with those in healthy individuals.
UNASSIGNED: The study involved 23 participants with serologically confirmed celiac disease (CD) and 23 control subjects. The CD patients had been following a gluten-free diet (GFD) for a minimum of 1 year and had no other autoimmune disorders. The research involved collecting demographic data, conducting periodontal examinations, gathering unstimulated whole saliva, and performing enzyme-linked immunosorbent assays to measure salivary interleukin-17A, interleukin-1 beta, and interleukin-18 levels. Spearman\'s correlation analysis was utilized to explore the relationships between CD markers in patients on a GFD and their periodontal clinical findings.
UNASSIGNED: The periodontal findings indicated significantly lower values in celiac disease patients adhering to a gluten-free diet compared to control subjects (p = 0.001). No significant differences were found in salivary IL-17A, IL-18, and IL-1B levels between celiac disease patients and control subjects. Nevertheless, the levels of all interleukins were elevated in periodontitis patients in both the celiac and control groups. The IL-1 Beta level was significantly higher in periodontitis patients compared to non-periodontitis patients in the control group (p = 0.035). Significant negative correlations were observed between serum IgA levels and plaque index (r = -0.460, p = 0.010), as well as gingival index (r = -0.396, p = 0.030) in CD patients on a gluten-free diet.
UNASSIGNED: Celiac disease patients on gluten-free diet exhibited better periodontal health compared to control subjects. However, increased levels of salivary IL-17A, IL-18 and IL-1B levels were associated with periodontitis. Additionally, serum IgA level was significantly inversely associated with periodontitis clinical manifestations and with salivary inflammatory mediators in CD patients on GFD.
UNASSIGNED: The study involved 23 participants with serologically confirmed celiac disease (CD) and 23 control subjects. The CD patients had been following a gluten-free diet (GFD) for a minimum of 1 year and had no other autoimmune disorders. The research involved collecting demographic data, conducting periodontal examinations, gathering unstimulated whole saliva, and performing enzyme-linked immunosorbent assays to measure salivary interleukin-17A, interleukin-1 beta, and interleukin-18 levels. Spearman\'s correlation analysis was utilized to explore the relationships between CD markers in patients on a GFD and their periodontal clinical findings.
UNASSIGNED: The periodontal findings indicated significantly lower values in celiac disease patients adhering to a gluten-free diet compared to control subjects (p = 0.001). No significant differences were found in salivary IL-17A, IL-18, and IL-1B levels between celiac disease patients and control subjects. Nevertheless, the levels of all interleukins were elevated in periodontitis patients in both the celiac and control groups. The IL-1 Beta level was significantly higher in periodontitis patients compared to non-periodontitis patients in the control group (p = 0.035). Significant negative correlations were observed between serum IgA levels and plaque index (r = -0.460, p = 0.010), as well as gingival index (r = -0.396, p = 0.030) in CD patients on a gluten-free diet.
UNASSIGNED: Celiac disease patients on gluten-free diet exhibited better periodontal health compared to control subjects. However, increased levels of salivary IL-17A, IL-18 and IL-1B levels were associated with periodontitis. Additionally, serum IgA level was significantly inversely associated with periodontitis clinical manifestations and with salivary inflammatory mediators in CD patients on GFD.
摘要：
■据记载，乳糜泻患者血清和肠粘膜中白介素-17A和白介素-18水平升高，反映了绒毛萎缩和炎症的严重程度。因此，这项研究的目的是评估唾液-17A的浓度，白细胞介素-1β，和白细胞介素18在乳糜泻患者中的无麸质饮食，有和没有牙周炎，并将这些水平与健康个体的水平进行比较。
■该研究涉及23名血清学证实为乳糜泻（CD）的参与者和23名对照受试者。CD患者接受无麸质饮食（GFD）至少1年，没有其他自身免疫性疾病。这项研究涉及收集人口统计数据，进行牙周检查，收集未受刺激的整个唾液，并进行酶联免疫吸附测定以测量唾液白细胞介素-17A，白细胞介素-1β，和白细胞介素-18水平。Spearman的相关分析用于探讨GFD患者的CD标记与其牙周临床表现之间的关系。
■牙周研究结果表明，与对照组相比，坚持无麸质饮食的乳糜泻患者的牙周值明显较低（p=0.001）。在唾液IL-17A中没有发现显著差异,乳糜泻患者和对照受试者之间的IL-18和IL-1B水平。然而，乳糜泻组和对照组牙周炎患者的所有白细胞介素水平均升高。与对照组的非牙周炎患者相比，牙周炎患者的IL-1β水平显着升高（p=0.035）。血清IgA水平与菌斑指数呈显著负相关(r=-0.460,p=0.010),以及无麸质饮食的CD患者的牙龈指数（r=-0.396，p=0.030）。
■与对照组相比，无麸质饮食的乳糜泻患者表现出更好的牙周健康状况。然而,唾液IL-17A水平升高，IL-18和IL-1B水平与牙周炎相关。此外,GFD患者血清IgA水平与牙周炎临床表现和唾液炎症介质呈显著负相关。
■该研究涉及23名血清学证实为乳糜泻（CD）的参与者和23名对照受试者。CD患者接受无麸质饮食（GFD）至少1年，没有其他自身免疫性疾病。这项研究涉及收集人口统计数据，进行牙周检查，收集未受刺激的整个唾液，并进行酶联免疫吸附测定以测量唾液白细胞介素-17A，白细胞介素-1β，和白细胞介素-18水平。Spearman的相关分析用于探讨GFD患者的CD标记与其牙周临床表现之间的关系。
■牙周研究结果表明，与对照组相比，坚持无麸质饮食的乳糜泻患者的牙周值明显较低（p=0.001）。在唾液IL-17A中没有发现显著差异,乳糜泻患者和对照受试者之间的IL-18和IL-1B水平。然而，乳糜泻组和对照组牙周炎患者的所有白细胞介素水平均升高。与对照组的非牙周炎患者相比，牙周炎患者的IL-1β水平显着升高（p=0.035）。血清IgA水平与菌斑指数呈显著负相关(r=-0.460,p=0.010),以及无麸质饮食的CD患者的牙龈指数（r=-0.396，p=0.030）。
■与对照组相比，无麸质饮食的乳糜泻患者表现出更好的牙周健康状况。然而,唾液IL-17A水平升高，IL-18和IL-1B水平与牙周炎相关。此外,GFD患者血清IgA水平与牙周炎临床表现和唾液炎症介质呈显著负相关。
